Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis

Table 1

Baseline characteristics and demographics of patients included.

References

Study type

Subtype of hemofiltration

Number

Age

Gender (male/female)

Etiological factors (gallstones/alcohol/hyperlipidemia/others)

Apache II score at admission

Amylase, μ/l

C-reactive protein, mg/L

Creatinine, μmol/L

Score

CH

CO

CH

CO

CH

CO

CH

CO

CH

CO

CH

CO

CH

CO

CH

CO

[15]

Randomized controlled trial

CVVH

10

10

57.7 ± 19.4

60.7 ± 11.4

6/4

6/4

NR

NR

14.7 ± 3.3

13.1 ± 1.5

NR

NR

NR

NR

NR

NR

2^b

[16]

Randomized controlled trial

CVVH

22

15

NR

NR

NR

NR

NR

NR

14.8 ± 4.5

14.6 ± 4.7

692 ± 273

680 ± 285

243 ± 18

242 ± 20

108 ± 21

109 ± 24

2^b

[17]

Randomized controlled trial

CVVH

33

30

49.3 (19–81)

50.7 (19–79)

18/15

16/14

18/8/4/3

15/6/5/4

15.3 ± 5.7

14.9 ± 5.1

942.7 ± 815.1

1060.3 ± 987.3

NR

NR

NR

NR

2^b

[18]

Randomized controlled trial

HVHF

30

30

44.1 ± 9.5

49.7 ± 17.0

21/9

18/12

NR

NR

15.3 ± 1.0

13.8 ± 3.6

NR

NR

NR

NR

235.3 ± 75.9

197.6 ± 61.2

2^b

[19]

Prospective study

HVHF

32

29

53.0 ± 15.7

48.2 ± 12.5

12/20

10/19

NR/7/4/21

N/6/5/18

19.3 ± 4.7

19.4 ± 4.4

NR

NR

155.1 ± 49

153.4 ± 51.31

NR

NR

8^c

[20]

Randomized controlled trial

Hemofiltration

32

32

52.31 ± 11.96

51.58 ± 12.64

21/11

23/9

NR

NR

20.37 ± 4.58

20.61 ± 3.58

NR

NR

29.81 ± 7.06

28.93 ± 7.24

126.30 ± 16.54

125.57 ± 15.81

2^b

[21]

Randomized controlled trial

CVVDH

65

60

46.5 ± 10.4

45.6 ± 11.2

35/30

33/27

24/13/15/13

25/13/11/11

15.97 ± 1.63

16.66 ± 1.70

NR

NR

NR

NR

NR

NR

3^b

[22]

Prospective study

HVHF

18

22

53.94 ± 16.46

50.55 ± 14.99

14/4

11/11

10/1/NR/7

10/0/NR/12

NR

NR

876.3 ± 178.0

619.9 ± 566.2

209.3 ± 171.4

227.8 ± 89.8

267 ± 48

263 ± 52

8^c

[23]

Randomized controlled trial

Hemofiltration

46

46

38.87 ± 6.47

39.13 ± 6.56

24/22

22/24

7/16/20/3

9/14/18/5

18.75 ± 3.04

18.93 ± 3.16

NR

NR

174.28 ± 9.25

173.84 ± 9.48

NR

NR

2^b

CH, continuous hemofiltration; CO, control; CVVH, continuous venovenous hemofiltration; CVVDH, continuous venovenous diahemofiltration; HVHF, high-volume hemofiltration. ^aSignificant difference. ^bRandomized clinical trial (RCT), and the Jadad scale points. ^cThe Newcastle–Ottawa Scale (NOS) score.