In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro

Figure 11

Illustrative presentation of the effects of the lidocaine-induced local anesthesia (intraplantar application (b) and axillar (d) and spinal (e) block) and corresponding BPC 157 counteraction ((a), (c), and (f)). Hind limb, plantar, and digits oedema in control rats (b) and counteraction in BPC 157 rats (a) immediately after 120 sec hot plate test. Fore limb, palmar, and fingers oedema in control rats (d) and counteraction in BPC 157 rats (c) presented at 30 min following lidocaine-induced axillary block. Presentation of the intrathecal anesthesia effect: prolonged hind limbs function failure and long-lasting flaccid paralysis (e) and recovery in BPC 157 rats (f) at 50 min following lidocaine.