In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro

Figure 5

Axillary block (function failure): left brachial plexus perineural anesthesia (white bars) produced considerable and long-lasting function failure of the affected fore limb and an inability to walk and to grasp. Therapy effect of the agents (saline 5 ml/kg, BPC 157 10 μg/kg, L-NAME 5 mg/kg, and L-arginine 100 mg/kg intraperitoneally, alone and/or together) given later at 10 minutes after lidocaine (gray bars indicate presentation at 10 min lidocaine-time). Perineural anesthesia of the nerves of the left brachial plexus, scored 0–5. (a) Saline (control). (b) L-NAME + L-arginine. (c) BPC 157. (d) L-NAME + BPC 157. (e) L-NAME. (f) L-NAME + BPC 157. (g) L-arginine. (h) L-NAME + L-arginine + BPC 157. Values are presented as min/med/max. at least vs. control.

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