In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro

Figure 9

Spinal block (function failure and flaccid paralysis): intrathecal anesthesia prolonged hind limbs function failure and long-lasting flaccid paralysis (white bars). The prophylactic effect of the agents given immediately after lidocaine, saline 5 ml/kg, BPC 157 10 μg/kg, L-NAME 5 mg/kg, and L-arginine 100 mg/kg intraperitoneally, alone and/or together. Intrathecal anesthesia at the L4-L5 level rat spine, scored 0–3. (a) Saline (control). (b) L-NAME + L-arginine. (c) BPC 157. (d) L-arginine + BPC 157. (e) L-NAME. (f) L-NAME + BPC 157. (g) L-arginine. (h) L-NAME + L-arginine + BPC 157. Values are presented as min/med/max. at least vs. control.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)