Prognostic Prediction Value of qSOFA, SOFA, and Admission Lactate in Septic Patients with Community-Acquired Pneumonia in Emergency Department

Table 4

ROC curve comparisons among severity scores and admission lactate in predicting ICU admission.

	AUC (95% CI)	value	Cutoff value	Sensi (%)	Speci (%)	PPV (%)	NPV (%)
CURB65	0.774 (0.709–0.840)	<0.001	3.0	83.6	60.0	31.7	94.3
CRB65	0.738 (0.667–0.810)	<0.001	3.0	59.0	79.6	39.1	89.7
PSI	0.837 (0.777–0.896)	<0.001	155	73.8	83.6	49.9	93.5
SOFA	0.895 (0.846–0.943)	<0.001	6.0	77.0	90.2	63.5	94.6
qSOFA	0.822 (0.769–0.874)	<0.001	2.0	96.7	50.5	30.2	98.6
Lactate	0.742 (0.669–0.816)	<0.001	2.0	55.7	77.1	35.0	88.7
CURB65 + lactate	0.818 (0.759–0.877)	<0.001	0.21	67.2	82.2	45.6	91.9
CRB65 + lactate	0.806 (0.741–0.870)	<0.001	0.16	77.0	74.9	40.5	93.6
PSI + lactate	0.840 (0.782–0.898)	<0.001	0.25	72.1	86.2	53.7	93.3
SOFA + lactate	0.902 (0.857–0.947)	<0.001	0.18	82.0	87.6	59.5	95.6
qSOFA + lactate	0.868 (0.823–0.912)	<0.001	0.14	83.6	78.2	46.0	95.6

ROC: area under the curve; CAP: community-acquired pneumonia; SCAP: severe community-acquired pneumonia; Sensi: sensitivity; Speci: specificity; PPV: positive predictive value; NPV: negative predictive value; CURB65: confusion, urea > 7 mmol/L, respiratory rate ≥ 30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; CRB65: confusion, respiratory rate ≥ 30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; PSI: pneumonia severity index; SOFA: sequential organ failure assessment; qSOFA: quick sequential organ failure assessment.