Prognostic Prediction Value of qSOFA, SOFA, and Admission Lactate in Septic Patients with Community-Acquired Pneumonia in Emergency Department

Table 5

ROC curve comparisons between CAP severity scores and admission lactate in predicting mechanical ventilation.

	AUC (95% CI)	value	Cutoff value	Sensi (%)	Speci (%)	PPV (%)	NPV (%)
CURB65	0.771 (0.713–0.829)	<0.001	3.0	78.3	62.1	40.4	89.7
CRB65	0.758 (0.697–0.820)	<0.001	3.0	59.0	83.0	53.2	86.1
PSI	0.780 (0.722–0.837)	<0.001	150	63.9	80.6	51.9	87.2
SOFA	0.845 (0.794–0.895)	<0.001	5.0	75.9	78.7	53.9	90.9
qSOFA	0.838 (0.789–0.887)	<0.001	2.0	94.0	53.8	40.0	96.5
Lactate	0.698 (0.628–0.768)	<0.001	2.0	49.4	77.9	42.3	82.4
CURB65 + lactate	0.804 (0.752–0.857)	<0.001	0.26	63.9	80.6	51.9	87.2
CRB65 + lactate	0.809 (0.755–0.864)	<0.001	0.21	75.9	76.7	51.7	90.7
PSI + lactate	0.796 (0.741–0.850)	<0.001	0.23	71.1	75.1	48.4	88.8
SOFA + lactate	0.851 (0.801–0.902)	<0.001	0.21	79.5	77.9	54.1	92.1
qSOFA + lactate	0.868 (0.826–0.911)	<0.001	0.26	71.1	88.9	67.8	90.4

ROC: area under the curve; CAP: community-acquired pneumonia; Sensi: sensitivity; Speci: specificity; PPV: positive predictive value; NPV: negative predictive value; CURB65: confusion, urea > 7 mmol/L, respiratory rate  ≥ 30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; CRB65: confusion, respiratory rate≥30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; PSI: pneumonia severity index; SOFA: sequential organ failure assessment; qSOFA: quick sequential organ failure assessment.