Prognostic Prediction Value of qSOFA, SOFA, and Admission Lactate in Septic Patients with Community-Acquired Pneumonia in Emergency Department

Table 6

ROC curve comparisons between CAP severity scores and admission lactate in predicting vasopressor use.

	AUC (95% CI)	value	Cutoff value	Sensi (%)	Speci (%)	PPV (%)	NPV (%)
CURB65	0.759 (0.705–0.814)	<0.001	3.0	75.0	64.9	50.3	84.6
CRB65	0.746 (0.688–0.803)	<0.001	3.0	53.7	85.1	63.1	79.5
PSI	0.767 (0.712–0.823)	<0.001	150.0	60.2	83.8	63.8	81.6
SOFA	0.821 (0.772–0.871)	<0.001	4.0	84.3	68.4	55.8	90.2
qSOFA	0.820 (0.772–0.868)	<0.001	2.0	90.7	57.5	50.3	92.9
Lactate	0.758 (0.700–0.817)	<0.001	2.0	57.4	84.6	68.7	81.3
CURB65 + lactate	0.824 (0.778–0.871)	<0.001	0.24	84.3	67.1	54.8	90.0
CRB65 + lactate	0.830 (0.782–0.877)	<0.001	0.31	75.0	80.3	64.3	87.1
PSI + lactate	0.820 (0.773–0.867)	<0.001	0.28	76.9	76.3	60.6	87.5
SOFA + lactate	0.848 (0.801–0.894)	<0.001	0.29	75.0	82.5	67.0	87.4
qSOFA + lactate	0.875 (0.835–0.915)	<0.001	0.38	69.4	89.9	76.5	86.1

ROC: area under the curve; CAP: community-acquired pneumonia; Sensi: sensitivity; Speci: specificity; PPV: positive predictive value; NPV: negative predictive value; CURB65: confusion, urea > 7 mmol/L, respiratory rate ≥ 30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; CRB65: confusion, respiratory rate ≥ 30/min, blood pressure < 90 mmHg systolic and/or ≤60 mmHg diastolic, and age ≥ 65 years; PSI: pneumonia severity index; SOFA: sequential organ failure assessment; qSOFA: quick sequential organ failure assessment.