Prognostic Utility of the Combination of Platelet Count with Neutrophil-to-Lymphocyte Ratio in Aged Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Table 1
Baseline characteristics.
Characteristics
Low PLC and low NLR (n = 145)
Either low PLC or low NLR (n = 351)
High PLC and high NLR (n = 141)
Age, year
72.40 ± 5.28
71.95 ± 5.20
72.31 ± 4.83
0.615
Gender (male), n (%)
105 (72.41)
227 (64.67)
85 (60.28)
0.088
Smoke and drink, n (%)
59 (40.69)
140 (39.89)
54 (38.30)
0.914
Hypertension, n (%)
85 (58.62)
205 (58.40)
89 (63.12)
0.610
Prior CHD, n (%)
23 (15.86)
37 (10.54)
12 (8.51)
0.116
Diabetes, n (%)
35 (24.14)
93 (26.50)
38 (26.95)
0.831
Stroke, n (%)
15 (10.34)
54 (15.38)
16 (11.35)
0.237
SBP on admission (mmHg)
130.99 ± 24.30
130.01 ± 24.07
125.53 ± 25.94
0.117
DBP on admission (mmHg)
75.18 ± 14.22
75.61 ± 14.09
74.77 ± 16.14
0.806
HR on admission (beats/min)
73.43 ± 11.25
77.08 ± 15.59
82.74 ± 19.67
<0.001
Pain to reperfusion (h)
16.70 ± 8.14
14.16 ± 8.99
12.32 ± 8.27
<0.001
Hospitalization day
8.28 ± 5.12
8.44 ± 6.43
10.21 ± 9.50
0.024
Killip class, III-IV, n (%)
11 (7.59)
50 (14.25)
37 (26.24)
<0.001
Diagnosis
STEMI
57 (39.31)
209 (59.54)
95 (67.38)
<0.001
NSTEMI
88 (60.69)
142 (40.46)
46 (32.62)
<0.001
LVEF (%)
55.86 ± 12.33
52.72 ± 12.21
49.92 ± 12.27
<0.001
Creatinine (μmol/l)
87.10 ± 26.91
92.98 ± 39.34
93.60 ± 35.44
0.202
AST (u/l)
55.45 ± 68.72
90.26 ± 106.13
136.06 ± 129.10
<0.001
ALT (u/l)
28.68 ± 39.30
36.15 ± 37.78
43.52 ± 44.94
0.007
NT-proBNP (pg/ml)
3863.64 ± 6575.65
4813.60 ± 7299.85
5702.91 ± 11031.69
0.161
CTnI (pg/ml)
10058.40 ± 15443.85
14747.61 ± 18692.72
22783.39 ± 20504.55
<0.001
HDL (mmol/l)
1.09 ± 0.41
1.08 ± 0.44
1.17 ± 0.50
0.124
LDL (mmol/l)
2.52 ± 0.92
2.52 ± 0.92
2.79 ± 1.09
0.012
Total triglyceride (mmol/l)
1.36 ± 0.81
1.39 ± 1.09
1.20 ± 1.08
0.169
Total cholesterol (mmol/l)
4.00 ± 1.07
4.04 ± 1.09
4.42 ± 1.25
0.001
WBC count (109/l)
6.97 ± 2.35
9.00 ± 3.19
12.37 ± 4.58
<0.001
PLC (109/l)
153.80 ± 26.76
201.10 ± 65.48
258.08 ± 62.10
<0.001
Neutrophil count (109/l)
4.62 ± 1.86
6.97 ± 3.32
10.70 ± 4.29
<0.001
Lymphocyte count (109/l)
1.67 ± 0.63
1.42 ± 0.68
1.02 ± 0.47
<0.001
Monocyte count (109/l)
0.52 ± 0.20
0.56 ± 0.28
0.61 ± 0.39
0.025
Hemoglobin (mg/dl)
129.19 ± 18.56
126.94 ± 19.25
123.43 ± 17.86
0.033
NLR
2.92 ± 1.03
6.61 ± 6.35
12.29 ± 7.17
<0.001
Medications in hospital, n (%)
Aspirin
140 (96.55)
338 (96.30)
132 (93.62)
0.356
Clopidogrel
135 (93.10)
337 (96.01)
131 (92.91)
0.244
Beta-blocker
108 (74.48)
250 (71.23)
94 (66.67)
0.342
ACEI/ARB
109 (75.17)
244 (69.52)
92 (65.25)
0.184
Statin
144 (99.31)
343 (97.72)
136 (96.45)
0.254
Mean ± SD and n (%) are reported for continuous and categorical variables, respectively. Abbreviations: SD, standard deviation; PLC, platelet count; NLR, neutrophil-to-lymphocyte ratio; COP-NLR, combination of platelet count and neutrophil-to-lymphocyte ratio; CHD, coronary heart disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; STEMI, ST-segment elevation myocardial infarction; NSTEMI, non-ST-elevation myocardial infarction; LVEF, left ventricular ejection fraction; AST, aspartate aminotransferase; ALT, alanine aminotransferase; NT-proBNP, N-terminal probrain natriuretic peptide; CTnI, cardiac troponin I; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; WBC, white blood cell; SII, systemic immune-inflammatory index; ACEI/ARB, angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker.
