Risk Factors for Mortality in Sepsis Patients without Lactate Levels Increasing Early
Table 4
Baseline data and fluid resuscitation comparison of patients in the high lactate group and the low lactate group.
Characteristic
Low lactate (n = 394)
High lactate (n = 436)
value
Baseline date
Male (%)
244 (61.9)
277 (63.5)
0.633b
Age (years)
63 (52–73)
63 (51–73)
0.719a
Weight (kg)
65 (55–70)
65 (55–70)
0.875a
Hospital stay (days)
18 (11–30)
15 (8–27)
<0.001a
ICU stay (days)
8 (4–15)
7 (3–14)
0.018a
Drinking history, yes (%)
45 (11.4)
51 (11.7)
0.901b
Smoking history, yes (%)
51 (12.9)
55 (12.6)
0.887b
Underlying disease, yes (%)
Hypertension
154 (39.1)
152 (34.9)
0.208b
Diabetes
84 (21.3)
95 (21.8)
0.870b
Chronic liver disease
16 (4.1)
31 (7.1)
0.058b
Chronic kidney disease
44 (11.2)
35 (8)
0.124b
Chronic respiratory disease
28 (7.1)
30 (6.9)
0.899b
Cardiovascular disease
78 (19.8)
83 (19)
0.782b
Autoimmune disease
27 (6.9)
37 (8.5)
0.378b
Malignancy
64 (16.2)
89 (20.4)
0.122b
Cerebrovascular disease
74 (18.8)
63 (14.4)
0.136b
Types of underlying disease ≥ 2
171 (43.4)
170 (39)
0.197b
Fluid resuscitation
Fluid resuscitation volume (3H) (mL)
250 (150–525)
398 (200–720)
<0.001a
Fluid resuscitation volume (6H) (mL)
714.5 (495.8–1106)
967 (621.5–1480)
<0.001a
Fluid resuscitation volume (12H) (mL)
1627 (1160–2120)
1966 (1372.5–2673)
<0.001a
Fluid resuscitation volume (24H) (mL)
3249 (2530–4074)
3701 (2949–4937.5)
<0.001a
Fluid resuscitation volume (3H) ≥ 30 mL/kg (%)
4 (1.0)
7 (1.6)
0.458b
Fluid resuscitation volume (6H) ≥ 30 mL/kg (%)
39 (9.9)
64 (14.7)
0.037b
Fluid resuscitation volume (12H) ≥ 30 mL/kg (%)
141 (35.8)
231 (53.0)
<0.001b
Fluid resuscitation volume (24H) ≥ 30 mL/kg (%)
350 (88.8)
415 (95.2)
0.001b
aNonparametric test: Mann-WhitneyU test. And the corresponding data were expressed as median (interquartile range). bChi-square tests and the corresponding data were expressed as numbers (percentages). 3H, 6H, 12H, and 24H, mean the first 3 hours, 6 hours, 12 hours, and 24 hours after ICU admission.
