Risk Factors for Mortality in Sepsis Patients without Lactate Levels Increasing Early
Table 6
Multivariate analysis of predictive factors for hospital mortality of patients in the low lactate group.
Variables
OR (95% CI)
value
Age
0.966 (0.945–0.987)
0.002
ICU stay
1.006 (0.985–1.028)
0.575
Chronic kidney disease
0.498 (0.174–1.427)
0.194
Cardiovascular disease
0.930 (0.406–2.127)
0.863
Malignancy
0.148 (0.061–0.359)
<0.001
Cerebrovascular disease
0.600 (0.256–1.407)
0.240
Types of underlying disease ≥ 2
0.932 (0.417–2.086)
0.864
Use of vasoactive drugs
4.745 (1.876–11.999)
0.001
Use of glucocorticoid
2.579 (1.321–5.034)
0.005
Mechanical ventilation
2.926 (1.151–7.442)
0.024
CRRT
3.079 (1.435–6.607)
0.004
APACHE II score
0.964 (0.904–1.027)
0.257
SOFA score
1.084 (0.963–1.220)
0.183
GCS score
1.065 (0.978–1.159)
0.148
Hb
1.006 (0.993–1.018)
0.385
RDW
0.956 (0.888–1.030)
0.235
TBIL
0.996 (0.988–1.005)
0.436
ALT
1.001 (1.000–1.002)
0.060
LDH
0.999 (0.999–0.9998)
0.006
Serum potassium
0.885 (0.601–1.303)
0.537
Serum sodium
0.982 (0.943–1.022)
0.364
HCO3
0.996 (0.944–1.051)
0.893
PCT
1.003 (0.995–1.011)
0.454
Fluid resuscitation volume (3H)
1.000 (0.999–1.002)
0.748
Fluid resuscitation volume (6H)
0.999 (0.997–1.000)
0.151
Fluid resuscitation volume (12H)
1.000 (0.999–1.001)
0.648
Fluid resuscitation volume (24H)
1.000 (1.000–1.001)
0.067
Albumin infusion volume (12H)
0.977 (0.946–1.009)
0.157
Albumin infusion volume (24H)
1.021 (0.998–1.045)
0.078
Fluid resuscitation volume (6H) ≥30 mL/kg
22.621 (2.987–171.333)
0.003
Fluid resuscitation volume (12H) ≥30 mL/kg
0.600 (0.247–1.457)
0.260
Note. The univariate significant indicators in Supplementary Table 2 were included in the multivariate logistic regression analysis. CRRT, continuous renal replacement therapy; APACHE II, acute physiology and chronic health evaluation II; SOFA, sepsis-related organ failure assessment; GCS, Glasgow coma scale; Hb, hemoglobin; RDW, red blood cell distribution width; TBIL, total bilirubin; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; HCO3, serum bicarbonate concentration; PCT, procalcitonin.
