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Enzyme Research
Volume 2011, Article ID 356093, 16 pages
Review Article

Acid Phosphatases of Budding Yeast as a Model of Choice for Transcription Regulation Research

Genetics and Breeding Department, Biology and Soil Sciences Faculty, Saint Petersburg State University, Universitetskaya emb. 7-9, Saint Petersburg 199034, Russia

Received 28 February 2011; Accepted 26 April 2011

Academic Editor: Hong-Jian Zhu

Copyright © 2011 Elena V. Sambuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acid phosphatases of budding yeast have been studied for more than forty years. This paper covers biochemical characteristics of acid phosphatases and different aspects in expression regulation of eukaryotic genes, which were researched using acid phosphatases model. A special focus is devoted to cyclin-dependent kinase Pho85p, a negative transcriptional regulator, and its role in maintaining mitochondrial genome stability and to pleiotropic effects of pho85 mutations.