Best Practices in Liver Biopsy Histologic Assessment for Nonalcoholic Steatohepatitis Clinical Trials: Expert Opinion

Table 2

Intra and interobserver agreement of the histologic interpretation of nonalcoholic steatohepatitis.

	Reference	Kappa coefficient
		Interobserver	Intraobserver
Steatosis	Younossi et al.	0.64	0.64^a
	Kleiner et al.	0.79	0.83
	Fukusato et al.	0.54	n.a.^b
	Gawrieh et al.	0.74^c	0.75^c
	Bedossa et al.	0.61^c	n.a.
	Davison et al.	0.61^d	0.75^e
	Sanyal AJ et al.	0.89	0.81
Ballooning	Younossi et al.	0.50	0.51^a
	Kleiner et al.	0.56	0.66
	Fukusato et al.	0.14	n.a.
	Gawrieh et al.	0.18^c	0.56^c
	Bedossa et al.	0.80^c	n.a.
	Davison et al.	0.52^d	0.66^e
	Sanyal AJ et al.	0.62	0.75
Lobular inflammation	Younossi et al.	0.33	0.62^a
	Kleiner et al.	0.45	0.60
	Fukusato et al.	0.10	n.a.
	Gawrieh et al.	0.20^c	0.48^c
	Bedossa et al.	0.72^c	n.a.
	Davison et al.	0.33	0.44^e
	Sanyal AJ et al.	0.60	0.61
Fibrosis stage	Younossi et al.	0.60	0.73^a
	Kleiner et al.	0.85	0.84
	Fukusato et al.	0.55	n.a.
	Gawrieh et al.	0.56^c	0.75^c
	Bedossa et al.	0.84^c	n.a.
	Davison et al.	0.48^d	0.78^d
	Sanyal AJ et al.	0.82	0.75

a = average, 2 observers; b = not analyzed; c = kappa value after the pathologists were trained by a tutorial; d = average, 3 observers; e = average, 2 observers and 2 different set of samples.