Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort

Table 2

Statistical analysis of the AFF3 polymorphism (rs340630) in RA cases and controls.

Statistical models	Genotypes	Cases (n = 409)	Controls (n = 294)	OR 95% CI	χ^2 value	value
Codominant	A/A	133 (32.52%)	105 (35.72%)	—	5.169	0.07
	A/G	210 (51.35%)	159 (54.09%)
	G/G	66 (16.14%)	30 1(0.21%)
Homozygous dominant	A/A	133 (32.5%)	105 (35.7%)	0.867	—	0.41
	A/G + G/G	276 (67.5%)	189 (64.3%)	(0.636–1.187)
Homozygous recessive	G/G	66 (16.1%)	30 (10.2%)	1.693	—	0.02
	A/A + A/G	343(83.9%)	264 (89.8%)	(1.06–2.648)
Heterozygous dominant	A/G	210 (51.3%)	159 (54%)	0.491	—	0.49
	A/A + G/G	199 (48.7%)	135 (46%)	(0.667–1.215)
Additive	A	476 (58.1%)	369(62.3%)	0.826	—	0.08
	G	342 (41.9%)	219 (37.3 %)	(0.665–1.027)