Pathophysiologic Mechanisms of Insulin Secretion and Signaling-Related Genes in Etiology of Polycystic Ovary Syndrome

Figure 1

Insulin resistance, producing factors and effective gene in each pathway, and ultimately insulin resistance by the formation of hyperinsulinemia and hyperandrogenism lead to PCOS. Insulin resistance can have different genetic, epigenetic (alteration during intrauterine development), and environmental origins or products derived from the adipose tissue. But, in PCOS condition, insulin resistance is mainly derived from postbinding receptor defects.