Pathophysiologic Mechanisms of Insulin Secretion and Signaling-Related Genes in Etiology of Polycystic Ovary Syndrome

Figure 3

The effect of pancreatic beta-cell dysfunctions on PCOS pathogenesis. Beta-cell dysfunctions lead to type 2 diabetes mellitus and hyperinsulinemia that lead to PCOS by creating hyperandrogenism. However, it is not clear that the PCOS is an introduction to beta-cell abnormalities and then resulted in insulin secretion dysregulation or vice versa.