Comprehensive Analysis of Genomic and Expression Data Identified Potential Markers for Predicting Prognosis and Immune Response in CRC

Figure 3

The dysregulation of somatically mutated genes was correlated to the prognosis of CRC. (a) 20 genes dramatically changed between the normal colon tissue and CRC group. Among them, DNAH5, TP53, OBSCN, LRP2, NEB, PCLO, MUC16, USH2A, and CCDC168 significantly upregulated. CSMD1, SYNE1, RYR1, RYR3, APC, ADGRV1M, DCHS2, KRAS, LRP1B, and FAT4 significantly downregulated. High expression of CSMD3 (b), DCHS2 (c), LRP2 (d), RYR2 (e), and ZFHX4 (f) significantly negatively correlated with shorter PFS in CRC.

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