Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis

Figure 4

Triptolide mitigates psoriatic symptoms of psoriatic mice induced by IMQ. BALB/c mice in the sham group were painted with vaseline daily. Mice in the model group and triptolide-treated groups were painted with IMQ daily. The triptolide groups were applied simultaneously with IMQ and triptolide (10 or 40 mg/kg). Skin lesion analysis was performed following sacrificing these mice. (a) Back skin photos of mouse models in the sham group, model group, model + triptolide (L) group, and model + triptolide (H) group taken on the 8th day after IMQ painting. (b) PASI scores of mouse models in each group evaluated daily. (c) The H&E-stained dorsal skin of mouse models in the indicated groups after IMQ treatment for 8 days. (d) Evaluation of epidermal thickness under a microscope via ImagePro Plus software. Each column is representative of data obtained from a minimum of 8 animals. ^## compared to the sham group; , compared to the model group.

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