Analysis of Long Noncoding RNAs-Related Regulatory Mechanisms in Duchenne Muscular Dystrophy Using a Disease-Related lncRNA-mRNA Pathway Network

<div>Identification of differentially expressed lncRNA (DELs) and differentially expressed mRNAs (DEMs) in Duchenne muscular dystrophy (DMD). (a) Volcano plots of DELs and DEMs in DMD based on the thresholds of false discovery rate (FDR) &lt; 0.05 and |log<sub>2</sub> fold change| &gt; 1. Blue and red spots represent downregulated and upregulated DELs/DEMs, respectively. (b) Bidirectional hierarchical clustering heatmap of DELs (upper) and DEMs (lower). (c) A Venn diagram of DEMs and DMD-related genes identified in the comparative toxicogenomics database (CTD) with the inference score &gt;3 set as the threshold.</div>

Genetics Research

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Figure 1: Analysis of Long Noncoding RNAs-Related Regulatory Mechanisms in Duchenne Muscular Dystrophy Using a Disease-Related lncRNA-mRNA Pathway Network 

Figure 1 | Analysis of Long Noncoding RNAs-Related Regulatory Mechanisms in Duchenne Muscular Dystrophy Using a Disease-Related lncRNA-mRNA Pathway Network 