Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics

Table 2

Genotype and allele frequencies of ET-1 rs5370 polymorphism.

Group		Control (%)	Case (%)	^a	OR	95% CI LL	95% CI UL
Genotype	TT	17 (8.7)	115 (65.0)	<0.001	62.574	30.31	129.179
	GT	31 (15.8)	46 (26.0)		13.726	6.898	27.313
	GG	148 (75.5)	16 (9.0)		Ref
Allele
	G	327 (83.4)	78 (22)	<0.001	Ref 17.801	12.344	25.671
	T	65 (16.6)	276 (78)
DOM	TT + GT	48 (24.5)	161 (91.00)	<0.001
RES	GG + GT	179 (91.3)	62 (35.0)	<0.001
	Post hoc test	Χ^2	value^a
	GG vs. GT	30.8	0.00001
	GG vs. TT	120.65	0.00001
	GT vs. TT	31.672	0.00001

Note: HOM MT = Homozygous mutant; HET = heterozygous; WT = wild type; DOM = dominant; RES = recessive. ^aChi-square test.