Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics

Table 4

Clinical and biochemical characteristics according to genotypes of ET-1 rs5370 gene polymorphism.

Parameter	Control (mean ± SD)				Case (mean ± SD)
	TT	GT	GG	^a	TT	GT	GG	^a
Age	36.41 ± 9.36	39.06 ± 9.64	40.35 ± 8.74	0.124	55.25 ± 8.37	56.33 ± 10	57.55 ± 9.5	0.565
BMI	22.71 ± 2.77	26.9 ± 5.63	25.12 ± 4.22	<0.001	23.81 ± 1.78	28.03 ± 4.17	29.76 ± 4.62	<0.001
WHR	0.92 ± 0.15	0.9 ± 0.16	0.88 ± 0.06	0.583	0.83 ± 0.06	0.91 ± 0.06	0.9 ± 0.11	0.016
FPG	5.39 ± 1.21	5.96 ± 1.92	5.68 ± 1.65	0.117	5.33 ± 2.98	6.22 ± 1.6	6.87 ± 2.56	0.041
HBA1C	2.35 ± 2.78	4.91 ± 2.67	2.27 ± 3.23	<0.001	6.29 ± 1.57	6.02 ± 1.44	6.69 ± 2.04	0.115
SBP	119.98 ± 9.64	125.16 ± 9.57	128.29 ± 12.58	<0.001	153.19 ± 10.02	159.15 ± 12.77	156.37 ± 12.06	0.194
DBP	77.45 ± 7.42	80.19 ± 7.34	81.29 ± 6.66	0.035	93.88 ± 5.43	95.8 ± 6.09	94.05 ± 5.75	0.207
CHOL	4.88 ± 0.96	4.56 ± 0.87	4.95 ± 0.83	<0.001	4.65 ± 0.95	4.94 ± 1.14	5.14 ± 1.1	0.188
LDL	2.62 ± 1	2.61 ± 0.73	2.88 ± 0.86	<0.001	2.57 ± 0.53	2.65 ± 0.92	2.99 ± 0.89	0.033
HDL	1.1 ± 0.36	1.16 ± 0.32	1.02 ± 0.36	0.395	1.16 ± 0.31	1.3 ± 0.46	1.24 ± 0.87	0.809
TG	1.51 ± 0.66	1.27 ± 0.49	1.48 ± 0.82	0.173	1.97 ± 1.08	1.65 ± 0.84	1.92 ± 1.04	0.279

Note: SD = Standard deviation; BMI = body mass index; WHR = waist-to-hip ratio; FPG = fasting plasma glucose; HbA1c = hemoglobin A1c; SBP = systolic blood pressure; DBP = diastolic blood pressure; Chol = cholesterol; LDL = low-density lipid; HDL = High-density lipid; TG = triglyceride. ^aOne-way ANOVA.