Nicotine Enemas for Active Crohn's Colitis: An Open Pilot Study

Table 1

Histological grade of inflammation. The histological grade of inflammation present in biopsies taken from the most inflamed area of the rectosigmoid region at sigmoidoscopy, adapted by GTW for Crohn’s colitis from the system described by Truelove and Richards [24] for ulcerative colitis.

Grade of inflammation	Description
0	No polymorphs
1	Small number of polymorphs in the lamina propria with minimal cryptitis
2	Focal cryptitis with crypt rupture or affecting groups of two or more adjacent crypts
3	Florid diffuse polymorph infiltrate with crypt abscesses
4	Florid acute inflammation with ulceration