Bone Health in a Nonjaundiced Population of Children with Biliary Atresia

Table 2

Multivariable regression models of lumbar spine and whole body BMC in biliary atresia versus control groups adjusting for age, gender, race and height.

		Coef.	Std. Err.	𝑡	𝑃>|𝑡|	𝑅^2
Lumbar spine BMC
Model 1	Female gender	0.04	0.03	1.38	0.169	0.82
	Black ethnicity	0.07	0.03	2.16	0.032
	Age	−1.36	0.39	−3.51	0.001
	Age^2	0.56	0.09	6.21	0.000
	Biliary atresia	−0.14	0.06	−2.21	0.028
	Intercept	3.38	0.41	8.26	0.000
Model 2	Female gender	0.04	0.02	1.60	0.112	0.90
	Black ethnicity	0.02	0.02	0.95	0.341
	Height	2.37	0.23	10.39	0.000
	Age	−1.58	0.41	−3.84	0.000
	Age^2	0.39	0.10	4.08	0.000
	Tanner stage 2	−0.05	0.04	−1.38	0.169
	Tanner stage 3	0.05	0.05	0.97	0.333
	Tanner stage 4	0.14	0.06	2.14	0.034
	Tanner stage 5	0.25	0.08	2.93	0.004
	Biliary atresia	−0.12	0.05	−2.58	0.011
	Intercept	−6.95	0.93	−7.45	0.000
Model 3	Female gender	0.03	0.02	1.52	0.080	0.90
	Black ethnicity	0.02	0.02	0.94	0.068
	Height	2.35	0.23	10.39	2.802
	Age	−1.34	0.43	−3.14	−0.498
	Age^2	0.34	0.10	3.43	0.536
	Tanner stage 2	−0.06	0.04	−1.47	0.019
	Tanner stage 3	0.06	0.05	1.10	0.166
	Tanner stage 4	0.15	0.06	2.31	0.272
	Tanner stage 5	0.26	0.08	3.06	0.420
	Biliary atresia	0.26	0.22	1.20	0.697
	Biliary atresia*Age	−0.19	0.11	−1.81	0.017
	Intercept	−7.14	0.93	−7.66	−5.303
Whole body BMC
Model 1	Female gender	0.02	0.03	0.78	0.435	0.85
	Black ethnicity	0.14	0.03	4.38	0.000
	Age	−0.50	0.40	−1.25	0.214
	Age^2	0.39	0.09	4.24	0.000
	Biliary atresia	−0.12	0.07	−1.90	0.059
	Intercept	5.93	0.42	14.01	0.000
Model 2	Female gender	0.02	0.02	0.73	0.467	0.93
	Black ethnicity	0.09	0.02	4.19	0.000
	Height	2.88	0.21	13.88	0.000
	Age	−1.65	0.29	−5.67	0.000
	Age^2	0.42	0.06	6.59	0.000
	Biliary atresia	−0.10	0.05	−2.18	0.031
	Intercept	−5.81	0.90	−6.48	0.000
Model 3	Female gender	0.01	0.02	0.58	0.563	0.93
	Black ethnicity	0.09	0.02	4.26	0.000
	Height	2.88	0.21	14.04	0.000
	Age	−1.44	0.30	−4.71	0.000
	Age^2	0.38	0.07	5.64	0.000
	Biliary atresia	0.35	0.21	1.69	0.094
	Biliary atresia*Age	−0.22	0.10	−2.21	0.028
	Intercept	−6.07	0.89	−6.79	0.000

* All continuous variables (spine and whole body BMC, age, and height) were natural log transformed.