Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2009 (2009), Article ID 425759, 9 pages
http://dx.doi.org/10.1155/2009/425759
Clinical Study

Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life

1Department of Gastroenterology, Copenhagen University Hospital (Rigshospitalet), 2121 Copenhagen, Denmark
2Department of Anesthesia, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark
3Department of Biomedical Sciences, The Panum Institute, 2200 Copenhagen, Denmark
4Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark

Received 24 March 2009; Accepted 29 May 2009

Academic Editor: Karel Geboes

Copyright © 2009 P. B. Jeppesen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. A. Byrne, D. W. Wilmore, K. Iyer et al., “Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial,” Annals of Surgery, vol. 242, no. 5, pp. 655–661, 2005. View at Publisher · View at Google Scholar
  2. D. J. Drucker, L. DeForest, and P. L. Brubaker, “Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2,” American Journal of Physiology, vol. 273, no. 6, pp. G1252–G1262, 1997. View at Google Scholar
  3. P. B. Jeppesen, B. Hartmann, J. Thulesen et al., “Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon,” Gastroenterology, vol. 120, no. 4, pp. 806–815, 2001. View at Google Scholar
  4. P. B. Jeppesen, E. L. Sanguinetti, A. Buchman et al., “Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant qlucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients,” Gut, vol. 54, no. 9, pp. 1224–1231, 2005. View at Publisher · View at Google Scholar · View at PubMed
  5. M. Bergner and R. A. Bobbitt, “The sickness impact profile: development and final revision of a health status measure,” Medical Care, vol. 19, no. 8, pp. 787–805, 1981. View at Google Scholar
  6. J. E. Ware, Jr. and C. D. Sherbourne, “The MOS 36-item short-form health survey (SF-36)—I: conceptual framework and item selection,” Medical Care, vol. 30, no. 6, pp. 473–483, 1992. View at Google Scholar
  7. G. Guyatt, A. Mitchell, E. J. Irvine et al., “A new measure of health status for clinical trials in inflammatory bowel disease,” Gastroenterology, vol. 96, no. 3, pp. 804–810, 1989. View at Google Scholar
  8. S. Heydorn, P. B. Jeppesen, and P. B. Mortensen, “Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome,” Scandinavian Journal of Gastroenterology, vol. 34, no. 8, pp. 818–823, 1999. View at Publisher · View at Google Scholar
  9. P. B. Jeppesen, E. Langholz, and P. B. Mortensen, “Quality of life in patients receiving home parenteral nutrition,” Gut, vol. 44, no. 6, pp. 844–852, 1999. View at Google Scholar
  10. S. J. D. O'Keefe, J. U. Burnes, and R. L. Thompson, “Recurrent sepsis in home parenteral nutrition patients: an analysis of risk factors,” Journal of Parenteral and Enteral Nutrition, vol. 18, no. 3, pp. 256–263, 1994. View at Google Scholar
  11. P. B. Jeppesen, M. Staun, and P. B. Mortensen, “Adult patients receiving home parenteral nutrition in Denmark from 1991 to 1996: who will benefit from intestinal transplantation?,” Scandinavian Journal of Gastroenterology, vol. 33, no. 8, pp. 839–846, 1998. View at Publisher · View at Google Scholar
  12. T. R. Beers, J. Burnes, and C. R. Fleming, “Superior vena caval obstruction in patients with gut failure receiving home parenteral nutrition,” Journal of Parenteral and Enteral Nutrition, vol. 14, no. 5, pp. 474–479, 1990. View at Google Scholar
  13. B. A. Bowyer, C. R. Fleming, J. Ludwig, J. Petz, and D. B. McGill, “Does long-term home parenteral nutrition in adult patients cause chronic liver disease?,” Journal of Parenteral and Enteral Nutrition, vol. 9, no. 1, pp. 11–17, 1985. View at Google Scholar
  14. A. N. Langnas, “Advances in small-intestine transplantation,” Transplantation, vol. 77, no. 9, pp. S75–S78, 2004. View at Google Scholar
  15. X. Guan, B. Stoll, X. Lu et al., “GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets,” Gastroenterology, vol. 125, no. 1, pp. 136–147, 2003. View at Publisher · View at Google Scholar
  16. A. Ugur, B. H. S. Marashdeh, I. Gottschalck, P. B. Mortensen, M. Staun, and P. B. Jeppesen, “Home parenteral nutrition in Denmark in the period from 1996 to 2001,” Scandinavian Journal of Gastroenterology, vol. 41, no. 4, pp. 401–407, 2006. View at Publisher · View at Google Scholar · View at PubMed