Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2009, Article ID 529802, 7 pages
http://dx.doi.org/10.1155/2009/529802
Research Article

Does Hypothyroidism Affect Gastrointestinal Motility?

1Department of Nuclear Medicine, Faculty of Medicine, Pamukkale University, Doktorlar Caddesi no. 42, Denizli 20100, Turkey
2Division of Gastroenterology, Faculty of Medicine, Pamukkale University Hospital, Kınıklı, Denizli 20020, Turkey
3Division of Endocrinology, Faculty of Medicine, Pamukkale University Hospital, Kınıklı, Denizli 20020, Turkey
4Department of Pathology, Faculty of Medicine, Pamukkale University Hospital, Kınıklı, Denizli 20020, Turkey
5Department of Biostatistics, Faculty of Medicine, Pamukkale University Hospital, Kınıklı, Denizli 20020, Turkey

Received 14 May 2009; Revised 7 August 2009; Accepted 9 December 2009

Academic Editor: Jan D. Huizinga

Copyright © 2009 Olga Yaylali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Gastrointestinal motility and serum thyroid hormone levels are closely related. Our aim was to analyze whether there is a disorder in esophagogastric motor functions as a result of hypothyroidism. Materials and Methods. The study group included 30 females (mean age ± SE 45.17 ± 2.07 years) with primary hypothyroidism and 10 healthy females (mean age ± SE 39.40 ± 3.95 years). All cases underwent esophagogastric endoscopy and scintigraphy. For esophageal scintigraphy, dynamic imaging of esophagus motility protocol, and for gastric emptying scintigraphy, anterior static gastric images were acquired. Results. The mean esophageal transit time (52.56 ± 4.07 sec for patients; 24.30 ± 5.88 sec for controls; ) and gastric emptying time (49.06 ± 4.29 min for the hypothyroid group; 30.4 ± 4.74 min for the control group; ) were markedly increased in cases of hypothyroidism. Conclusion. Hypothyroidism prominently reduces esophageal and gastric motor activity and can cause gastrointestinal dysfunction.