Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population

Table 5

Allelic odds ratios and 95% confidence intervals for comparison of TNFRSF1B variants with IBD status in New Zealand IBD patients and Caucasians.

	Allelic odds ratios and 95%				Allelic odds ratios and 95%				Allelic odds ratios and 95%
	confidence intervals for comparison of				confidence intervals for comparison of				confidence intervals for comparison of
	TNFRSF1_B1061622				TNFRSF1B_1061624				TNFRSF1B_3397
	Crohns disease		Ulcerative colitis		Crohns disease		Ulcerative colitis		Crohns disease		Ulcerative colitis
	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
Female	1.20	0.86-1.67	1.38	0.99-1.93	1.10	0.84-1.44	1.00	0.76-1.32	0.85	0.65-1.12	0.96	0.72-1.27
Male	1.05	0.72-1.54	1.02	0.72-1.45	0.82	0.59-1.14	0.79	0.59-1.07	0.89	0.64-1.24	1.04	0.76-1.42
Age at first diagnosis
0–16 years	0.85	0.47-1.54	1.08	0.55-2.11	0.88	0.55-1.42	1.30	0.74-2.29	0.86	0.53-1.39	1.22	0.67-2.22
17–40 years	1.26	0.94-1.68	1.18	0.87-1.59	1.01	0.79-1.29	0.93	0.72-1.20	0.85	0.66-1.09	0.96	0.74-1.25
>40 years	1.01	0.73-1.41	1.24	0.93-1.66	0.95	0.72-1.25	0.83	0.65-1.07	0.89	0.67-1.17	1.00	0.77-1.29
CD location
Ileal	0.91	0.63-1.30			1.13	0.85-1.51			0.88	0.65-1.18
Colonic	1.17	0.86-1.59			0.90	0.69-1.17			0.91	0.70-1.19
Ileocolonic	1.27	0.87-1.86			0.90	0.64-1.26			0.78	0.56-1.09
UC location
Pancolitis			1.13	0.82-1.56			0.94	0.72-1.23			1.14	0.86-1.51
Left colon			1.24	0.87-1.78			0.73	𝟎.𝟓𝟒-𝟏.𝟎𝟎			0.92	0.67-1.26
Proctitis			1.27	0.92-1.76			1.00	0.76-1.32			0.93	0.70-1.24
CD Behavior
Inflammatory	1.17	0.88-1.56			0.88	0.69-1.12			0.92	0.72-1.18
Stricturing	1.03	0.72-1.47			1.01	0.75-1.36			0.90	0.67-1.22
Penetrating	1.13	0.68-1.87			1.38	0.90-2.12			0.62	𝟎.𝟒𝟎-𝟎.𝟗𝟓
Ileal/stricturing	0.86	0.55-1.34			1.03	0.72-1.46			0.93	0.65-1.33
Colonic/inflammatory	1.24	0.90-1.71			0.84	0.64-1.11			0.93	0.70-1.23
Any relative with IBD	1.22	0.80-1.86	1.15	0.74-1.79	0.78	0.54-1.12	0.88	0.60-1.28	0.97	0.67-1.40	0.83	0.57-1.22
Bowel resection	0.93	0.66-1.31	1.10	0.71-1.70	1.09	0.83-1.44	0.79	0.55-1.14	0.77	0.58-1.02	1.29	0.87-1.90
Smoker at diagnosis	0.96	0.65-1.42	1.16	0.71-1.90	1.01	0.73-1.39	0.62	0.40-0.96	0.92	0.66-1.28	1.22	0.78-1.91
Ever used immunomodulators	1.08	0.80-1.45	1.43	0.98-2.09	1.07	0.84-1.37	1.16	0.83-1.62	0.82	0.64-1.05	0.88	0.63-1.24
Any EIMs	1.05	0.68-1.61	1.05	0.66-1.66	1.06	0.74-1.51	0.83	0.57-1.21	0.89	0.62-1.28	0.81	0.55-1.19