Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function

Table 2

Schedule of procedures and evaluations.

	1st year				2nd year
	Baseline	Week 13	Week 26	Week 52	Washout (8 weeks post-treatment)	Week 13	Week 26	Week 52
Treatment	None	GLP-2	GLP-2	GLP-2	None	GLP-2	GLP-2 + Cholyl-sarcosine*	GLP-2
Intestinal biopsy (morphometry)	×			×
72-h balance on diet, feces, urine (wet weight, na+, k+, mg2+, ca2+, energy, fat, carbohydrate, protein)	×	×	×	×	×	×	×	×
72-h Urinary creatinine excretion	×	×	×	×	×	×	×	×
DEXA (body weight + body composition + bone mineral content)	×	×	×	×	×	×	×	×
Vitamin D, PTH	×	×	×	×	×	×	×	×
Bone resorption and formation markers(s-crosslabs, osteocalcin)	×	×	×	×	×
NMR scan	×	×
lung function + in- and expiratory force	×	×	×	×
exercise test on bike	×	×

*Cholylsarcosine was given two days prior to the admission and during the 72-hour balance studies.