Gastroenterology Research and Practice / 2009 / Article / Tab 2

Clinical Study

Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function

Table 2

Schedule of procedures and evaluations.

1st year2nd year

BaselineWeek 13Week 26Week 52Washout (8 weeks post-treatment)Week 13Week 26Week 52
TreatmentNoneGLP-2GLP-2GLP-2NoneGLP-2GLP-2 + Cholyl-sarcosine*GLP-2
Intestinal biopsy (morphometry)
72-h balance on diet, feces, urine (wet weight, na+, k+, mg2+, ca2+, energy, fat, carbohydrate, protein)
72-h Urinary creatinine excretion
DEXA (body weight + body composition + bone mineral content)
Vitamin D, PTH
Bone resorption and formation markers(s-crosslabs, osteocalcin)
NMR scan
lung function + in- and expiratory force
exercise test on bike

*Cholylsarcosine was given two days prior to the admission and during the 72-hour balance studies.

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