Gastroenterology Research and Practice / 2009 / Article / Tab 2 / Clinical Study
Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function Table 2 Schedule of procedures and evaluations.
1st year 2nd year Baseline Week 13 Week 26 Week 52 Washout (8 weeks post-treatment) Week 13 Week 26 Week 52 Treatment None GLP-2 GLP-2 GLP-2 None GLP-2 GLP-2 + Cholyl-sarcosine* GLP-2 Intestinal biopsy (morphometry)
72-h balance on diet, feces, urine (wet weight, na+, k+, mg2+, ca2+, energy, fat, carbohydrate, protein)
72-h Urinary creatinine excretion
DEXA (body weight + body composition + bone mineral content)
Vitamin D, PTH
Bone resorption and formation markers(s-crosslabs, osteocalcin)
NMR scan
lung function + in- and expiratory force
exercise test on bike
*Cholylsarcosine was given two days prior to the admission and during the 72-hour balance studies.