Gastroenterology Research and Practice

Clinical Study

Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function

Table 7

³¹PMRS measurements on primarily red (tibialis anterior) or white (forearm) skeletal muscle of subjects before treatment with GLP2. Tibialis anterior represents a primarily “red” and the forearm flexor group a primarily “white” muscle. The first 4 lines are recorded at rest where PCr is given as mM. The subsequent 4 lines are recorded after a 1 min of maximal contraction. The PCr and pH change is the difference between the resting value and the value measured by the end of exercise. The T_0.5 values are half times for recovery (s), assuming monoexponential recovery after exercise (27).


	Forearm Flexors	Tibialis Anterior

At rest:
PCr	24.3 ± 1.7	23.5 ± 2.3
PCr/ATP	4.2 ± 0.5	4.3 ± 0.4
PCr/Pi	7.7 ± 1.9	6.0 ± 1.5*
pH	7.04 ± 0.04	6.99 ± 0.05^**
After exercise:
PCr change	14.0 ± 3.3	13.7 ± 5.7
pH change	0.46 ± 0.29	0.18 ± 0.17*
	59.6 ± 16.0	45.1 ± 11.0
	34.8 ± 12.0⁺	26.7 ± 7.0⁺
	0.25 ± 0.08	0.27 ± 0.19

* and ^** for arm versus leg. ⁺ for versus .