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Gastroenterology Research and Practice
Volume 2009, Article ID 623871, 4 pages
Research Article

Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis

1Pediatric Gastroenterology Unit, Department of Pediatrics, Bikur Cholim General Hospital, P. O. Box 492, Jerusalem 91004, Israel
2Department of Pediatrics, Bikur Cholim General Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel
3Medical Administration, Kaplan-Harzfeld Medical Center, Rehovot, Israel
4Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Received 10 December 2008; Revised 15 March 2009; Accepted 2 April 2009

Academic Editor: Karel Geboes

Copyright © 2009 A. Klar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decrease in venous return due to dehydration would lead to a decrease in ANP levels. Patients and Methods. This is a prospective observational controlled study. Blood collected from 30 children with AGE and ANP's levels were compared with 25 controls. ANP levels were determined by radioimmunoassay. Results. The study group was in mild dehydration. As a significant difference was found in ANP levels between children in the 3mo–3y group and older children 3y–14y. We analyzed the results according to age. No difference was found between children with AGE and control, in the 3mo–3y, ANP was 12.1 11 pg/ml versus 13.4 12 pg/ml respectively, and 3 2 versus 3.8 3 pg/ml in the 3y–14y groups, respectively. Conclusion. Dehydration due to AGE does not change the ANP's plasma levels. A weak positive correlation between sodium levels and ANP was found . The significant finding of our study is the difference in ANP levels related to age, in the control as well as the GE group.