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Gastroenterology Research and Practice
Volume 2009 (2009), Article ID 679830, 7 pages
http://dx.doi.org/10.1155/2009/679830
Research Article

Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas

1Digestive Service, Hospital Universitario Miguel Servet, 50009, Zaragoza, Spain
2Department of Pathology, Hospital Clínico Universitario Lozano Blesa, 50009, Zaragoza, Spain
3Department of Emergency, Hospital Universitario Miguel Servet, 50009, Zaragoza, Spain

Received 9 March 2009; Accepted 23 August 2009

Academic Editor: Andrew Thillainayagam

Copyright © 2009 Rafael Uribarrena A et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die. Method. In order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of 104 Dukes A-B CRC patients were retrospectively studied. Immunohistochemistry was performed for anti-CD34 antibody to visualize tumor vascularisation. MVD was expressed as the total number of vessels and as the percentage of microvascular area. We calculated MVD with a morphometry program and performed descriptive, bivariate, and survival statistics. Results. The mean number of vessels was 37.37/200x field, and the mean vascular area was the 3.972%. 30% of the patients with  vessels/field, and 21% of the patients with  vessels/field, experienced recurrence/death. The 35% of patients with % of vascular area died following recurrence, compared with 14% of patients with ≥4% of vascular area. These differences in % of vascular area were statistically significant. Conclusion. MVD expressed as the total number of vessels had no a statistically significant influence on the evolution of CRC. However, neoplasias with a greater % of vascular were associated to a better outcome.