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Gastroenterology Research and Practice
Volume 2009, Article ID 947014, 7 pages
http://dx.doi.org/10.1155/2009/947014
Research Article

Clinical Relevance of Transjugular Liver Biopsy in Comparison with Percutaneous and Laparoscopic Liver Biopsy

1Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Straße 1, 30625 Hannover, Germany
2Department of Gastroenterology, Sana clinic Lübeck, Kronsorder Allee 17-73, 23560 Lübeck, Germany
3Department of Pathology, Medical School Hannover, Carl Neuberg Straße 1, 30625 Hannover, Germany
4Integrated Research and Treatment Center-Transplantation (IFB-Tx), Medical School Hannover, Carl Neuberg Straße 1, 30625 Hannover, Germany

Received 16 March 2009; Revised 17 July 2009; Accepted 2 September 2009

Academic Editor: Bob Grover

Copyright © 2009 Max G. Beckmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Transjugular liver biopsy (TJLB) is frequently used to obtain liver specimens in high-risk patients. However, TJLB sample size possibly limits their clinical relevance. Methods. 102 patients that underwent TJLB were included. Clinical parameters and outcome of TJLB were analyzed. Control samples consisted of 112 minilaparoscopic liver biopsies (mLLBs) and 100 percutaneous liver biopsies (PLBs). Results. Fewer portal tracts were detected in TJLB ( ) in comparison with PLB ( ) and mLLB ( ). No difference regarding the specification of indeterminate liver disease and staging/grading of chronic hepatitis was observed. In acute liver failure ( ), a proportion of hepatocellular necrosis beyond 25% was associated with a higher rate of death or liver transplantation. Conclusions. Despite smaller biopsy samples the impact on the clinical decision process was found to be comparable to PLB and mLLB. TJLB represents a helpful tool to determine hepatocellular necrosis rates in patients with acute liver failure.