LPS-Toll-Like Receptor-Mediated Signaling on Expression of Protein S and C4b-Binding Protein in the Liver
Figure 5
Mechanism of LPS-induced decreased expression of PS and C4BP in hepatocytes. LPS binds to membrane-bound CD14 and TLR-4, followed by activation of MEK/ERK and NFB. Activated NFB interacts with the promoter regions of the PS and C4BP and C4BP genes, leading to decreased PS expression in hepatocytes and SECs, and decreased C4BP expression in hepatocytes.
