Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance

Figure 5

Effects of strain and ethanol Exposure on alcohol metabolizing gene expression in liver: qRT-PCR assays were used to measure (a), (b) alcohol dehydrogenases (ADH) 1 and 7, (c)–(e) aldehyde dehydrogenases (ALDH) 1-3, (f) Catalase, and (g) CYP2E1 gene expression. Graphs depict the mean ± S.E.M. levels of gene expression normalized to 18S rRNA. Intergroup comparisons were made using ANOVA with the post hoc Bonferroni multiple comparisons test of significance. Significant 𝑃-values are indicated within the panels. In addition, ^∗𝑃<.05 and ^∗∗∗𝑃<.001 relative to FS Control; 𝜁𝑃<.05,𝜁𝜁𝑃<.01 relative to FS control and ethanol fed rats; ψ ψ𝑃<.01 and ψ ψψ 𝑃<.001 relative to FS ethanol-fed rats.

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