Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance

Figure 7

Effects of strain and ethanol exposure on hepatic gene expression: qRT-PCR assays were used to measure (a) albumin, (b) asialobiliary salt transporter (ABST), (c) Kupffer cell receptor gene, (d) glial fibrillary acidic protein (GFAP), (e) desmin, (f) 𝛼-smooth muscle actin (𝛼-SMA), and (g) collagen, with levels normalized to 18S rRNA. Graphs depict the mean ± S.E.M. levels of gene expression. Intergroup comparisons were made using ANOVA with the post hoc Bonferroni multiple comparisons test of significance. Significant 𝑃-values are indicated within the panels. In addition, ζ 𝑃<.05,ζ ζ𝑃<.01 relative to FS control and ethanol fed rats.

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