Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance

Table 2

Weight gain after 8 weeks on isocaloric liquid diets^∗.

	FS Control	FS Ethanol	LE Control	LE Ethanol	SD Control	SD Ethanol
# Rats/Group	12	14	12	13	12	13
Wt Gain (gm)	82.68	55.49c,d	75.05 e	64.18 b	104.4	90.88
± S.E.M.	5.35	3.83	6.49	6.92	7.93	6.86
% Wt Gain	30.63	21.16 a,b	21.04 a,b	19.59 a,b	34.75	30.02
S.E.M.	1.98	1.42	1.77	2.32	2.73	2.34

∗Adult Fisher (FS), Long Evans (LE), and Sprague-Dawley (SD) rats were pair-fed with isocaloric control or ethanol-containing liquid diets for 8 weeks, and were weighed weekly (See Section 2). Net mean body weight (grams) and mean percentage body weight gained over the 8 week period were calculated. Intergroup comparisons were made using two-way ANOVA and Tukey post hoc tests of significance. asignificantly lower than FS Control (𝑃<.05); bsignificantly lower than SD Control (𝑃<.001) and SD Ethanol (𝑃<.05); csignificantly lower than FS Control (𝑃<.05); dsignificantly lower than SD Control (𝑃<.001) and SD Ethanol (𝑃<.01); andesignificantly lower than SD Control (𝑃<.05).