SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases
Figure 2
Proposed inhibitory mechanisms of SOCS1 on TLR signaling. The absence of SOCS1 results in heightened response to TLR ligands. Possible mechanisms of action of SOCS1 proposed so far are outlined here. Upon induction, SOCS1 binds to Mal/TIRAP and mediates its degradation via proteasomal pathway (1). SOCS1 binds to IRAK and may modulate its activity (2). SOCS1 binds to p65 subunit of NFB and targets it for proteasomal degradation (3). SOCS1 inhibits JAK2 activated directly after TLR stimulation (4). SOCS1 regulates TLR-mediated response indirectly by inhibition of TLR-induced cytokines such as IFN- (5).
