SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases

Table 1

Inducing factors of SOCS family proteins and suppressed signaling by SOCS family proteins (see [1, 3, 4]).

SOCS family	Inducers	Suppressed Signaling*
CIS	IL-2, IL-3, EPO, GM-CSF, GH, Prolactin	IL-2, IL-3, EPO, GH, Prolactin
SOCS-1	IL-2, IL-3, IL-4, IL-6, IL-7, IL-9, IL-10, IL-13, IL-15, IL-21, IFN-𝛼/𝛽, IFN-𝛾, LIF, TNF-𝛼, TGF-𝛽, EPO, G-CSF, SCF, GH, TSH, Prolactin, CNTF, Cardiotrophin, Insulin, LPS, CpG DNA	IL-2, IL-4, IL-6, IL-7, IL-12, IL-15, IL-21, IFN- 𝜶/𝜷, IFN- 𝜸, LIF, TNF- 𝜶, EPO, TPO, TSLP, SCF, GH, Prolactin, Insulin, LPS, CpG DNA
SOCS-2	IL-2, IL-6, EPO, GH, Prolactin, Insulin, CNTF,	IL-6, GH, IGF-I
SOCS-3	IL-1, IL-2, IL-3, IL-4, IL-6, IL-9, IL-10, IL-11, IL-12, IL-22, IL-23, IL-27, IFN-𝛼/𝛽, IFN-𝛾, LIF, TNF-𝛼, TGF-𝛽, EPO, TPO, G-CSF, GH, TSH, Prolactin, Leptin, CNTF, Cardiotrophin, EGF, Insulin	IL-1, IL-2, IL-4, IL-6, IL-9, IL-11, IL-27, IFN-𝛼/𝛽, IFN-𝛾, LIF, OSM, EPO, G-CSF, GH, Prolactin, Leptin, CNTF, Cardiotrophin, Insulin, LPS
SOCS-4	EGF	EGF
SOCS-5	EGF	IL-4, IL-6, EGF
SOCS-6	SCF, Insulin	SCF, Insulin
SOCS-7	Insulin, IGF-1	Insulin

*Signaling shown in red is demonstrated in the studies using knockout mice.