SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="left">Mechanism for SOCS1 dysregulation</td><td align="left">Pathogenic consequences in liver</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left" rowspan="2">Increased SOCS1</td><td align="left" rowspan="2">(1) Excessive stimulation with    cytokines/TLR ligands</td><td align="left">Insulin resistance</td></tr><tr><td align="left">Reduced liver regeneration</td></tr><tr><td align="center" colspan="3"><hr/></td></tr><tr><td align="left" rowspan="3">Reduced SOCS1</td><td align="left">(1) CpG methylation</td><td align="left">Hepatitis</td></tr><tr><td align="left">(2) Promoter polymorphism?</td><td align="left">Liver fibrosis</td></tr><tr><td align="left">(3) Genetic mutation?</td><td align="left">Hepatocellular carcinoma</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Proposed involvement of SOCS1 in liver pathophysiology.

Gastroenterology Research and Practice

tab2

Table 2

Table 2: SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases 

Gastroenterology Research and Practice

SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases

Table 2