Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2010 (2010), Article ID 539461, 12 pages
http://dx.doi.org/10.1155/2010/539461
Research Article

IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population

1Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand
2Nutrigenomics, New Zealand
3Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand

Received 13 July 2010; Accepted 2 November 2010

Academic Editor: Antoni Castells

Copyright © 2010 Lynnette R. Ferguson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

DNA samples from 339 Crohn's disease (CD) and 407 randomly selected controls from the Auckland (New Zealand) IBD project, were genotyped for five common single nucleotide polymorphisms in IL-23R (rs11805303, rs7517847, rs1343151, rs11209026, and rs10889677) and two in IL-12B (rs1363670 and rs6887695). While the IL-12B variants did not show an overall association and other IL23R variants led to minor changes in the risk of CD, rs1343151 and/or rs7517847 variants in the IL-23R gene strongly reduced the risk of developing CD at both allelic and genotype levels. A significantly decreased risk of first diagnosis of childhood CD was observed in individuals carrying the A allele of rs1343151, or between 17–40 y in individuals carrying the G allele in rs7517847 of IL-23R. A significantly decreased risk of ileocolonic or structuring disease was observed in individuals carrying the A allele in either rs11209026 or rs1343151, or the G allele in rs7517847 of IL-23R, and when such individuals did develop the disease, they were unlikely to require a bowel resection. Certain haplotypes very strongly modified risk. There was evidence for interactions of IL-23R variants with the NOD2 wild-type (d/d) genotype. Down-regulating the function of the IL-23R gene may decrease CD risk in the normal population.