IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population

Table 3

Allelic odds ratios and 95% CI for comparison of IL-12B variants of carriage of the minor alleles with IBD phenotype.

(a)

	IL-12B rs1363670		IL-12B rs6887695
	OR (95% CI)	𝑃 value	OR (95% CI)	𝑃 value
Gender
Female	1.54 (0.96–2.46)	0.086	0.79 (0.57–1.10)	.178
Male	0.85 (0.51–1.42)	0.608	0.93 (0.66–1.32)	.725
Age at first diagnosis
0–16 years	1.41 (0.69–2.89)	0.317	0.76 (0.42–1.37)	.394
17–40 years	1.28 (0.90–1.81)	0.175	0.92 (0.71–1.19)	.513
>40 years	0.84 (0.43–1.63)	0.747	0.73 (0.46–1.15)	.184
CD location
Colonic	1.16 (0.71–1.89)	0.523	0.94 (0.66–1.34)	.790
Ileal	1.39 (0.89–2.16)	0.153	0.55 (0.38–0.80)	.002
Ileocolonic	1.11 (0.68–1.80)	0.703	1.26 (0.89–1.79)	.206
CD behaviour
Inflammatory	1.23 (0.84–1.81)	0.313	0.83 (0.62–1.11)	.220
Penetrating	0.46 (0.16–1.30)	0.161	1.06 (0.61–1.83)	.888
Stricturing	1.60 (1.01–2.53)	0.055	0.85 (0.59–1.23)	.408
Colonic/inflammatory	1.16 (0.69–1.96)	0.580	0.82 (0.56–1.21)	.332
Ileal/stricturing	1.86 (1.08–3.20)	0.036	0.58 (0.35–0.96)	.035
Any relatives with IBD	1.43 (0.91–2.25)	0.137	0.96 (0.68–1.36)	.859
Bowel resection	1.22 (0.77–1.92)	0.401	0.91 (0.65–1.28)	.609
Smoker at diagnosis	1.47 (0.79–2.74)	0.282	0.91 (0.60–1.39)	.668
Any EIMs	1.33 (0.73–2.42)	0.327	1.1 (0.70–1.74)	.724

(b)

	IL23R rs10889677		IL23R rs11209026		IL23R rs11805303		IL23R rs1343151		IL23R rs7517847
	OR (95% CI)	𝑃	OR (95% CI)	𝑃	OR (95% CI)	𝑃	OR (95% CI)	𝑃	OR (95% CI)	𝑃
Gender
Female	0.93 (0.67–1.29)	0.739	0.57 (0.31–1.05)	0.086	1.24 (0.89–1.73)	0.210	0.67 (0.48–0.94)	0.024*	0.79 (0.57–1.09)	.144
Male	0.75 (0.53–1.05)	0.113	0.51 (0.23–1.16)	0.119	1.32 (0.93–1.86)	0.129	0.67 (0.47–0.96)	0.028*	0.69 (0.49–0.97)	.041*
Age at first diagnosis
0–16 years	0.60 (0.35–1.02)	0.064	0.24 (0.03–1.75)	0.175	1.56 (0.90–2.69)	0.110	0.41 (0.21–0.80)	0.007*	0.63 (0.36–1.10)	.105
17–40 years	0.81 (0.63–1.05)	0.116	0.61 (0.36–1.04)	0.073	1.32 (1.02–1.70)	0.041	0.62 (0.47–0.81)	0.0006*	0.65 (0.50–0.84)	.0008*
>40 years	0.76 (0.49–1.17)	0.216	0.73 (0.29–1.84)	0.675	1.34 (0.87–2.08)	0.205	0.84 (0.54–1.31)	0.506	0.91 (0.60–1.38)	.750
CD location
Colonic	0.80 (0.57–1.13)	0.211	0.69 (0.33–1.45)	0.406	1.27 (0.90–1.80)	0.202	0.79 (0.55–1.13)	0.210	1.04 (0.74–1.45)	.864
Ileal	0.77 (0.55–1.07)	0.140	0.68 (0.34–1.38)	0.346	1.40 (1.00–1.95)	0.055	0.68 (0.48–0.97)	0.037*	0.62 (0.44–0.87)	.005*
Ileocolonic	0.76 (0.54–1.08)	0.123	0.34 (0.12–0.94)	0.026	1.38 (0.97–1.96)	0.080	0.43 (0.28–0.65)	0.00004*	0.52 (0.36–0.75)	.0003*
CD behaviour
Inflammatory	0.78 (0.59–1.03)	0.096	0.73 (0.42–1.28)	0.296	1.31 (0.99–1.74)	0.067	0.69 (0.51–0.93)	0.013*	0.82 (0.62–1.08)	.165
Penetrating	0.76 (0.45–1.29)	0.333	0.23 (0.03–1.68)	0.179	1.40 (0.82–2.39)	0.255	0.38 (0.20–0.74)	0.003*	0.53 (0.30–0.92)	.025*
Stricturing	0.76 (0.53–1.09)	0.136	0.35 (0.13–0.97)	0.037	1.47 (1.03–2.10)	0.040	0.60 (0.40–0.89)	0.014*	0.56 (0.39–0.81)	.002*
Colonic/; inflammatory	0.80 (0.55–1.16)	0.243	0.63 (0.27–1.47)	0.363	1.26 (0.86–1.84)	0.274	0.76 (0.51–1.13)	0.206	1.05 (0.73–1.51)	.852
Ileal/stricturing	0.80 (0.51–1.26)	0.345	0.30 (0.07–1.24)	0.082	1.54 (0.98–2.41)	0.072	0.69 (0.42–1.13)	0.155	0.59 (0.37–0.94)	.032*
Any relatives with IBD	0.89 (0.63–1.26)	0.529	0.49 (0.21–1.14)	0.099	1.22 (0.86–1.73)	0.278	0.62 (0.43–0.90)	0.015*	0.64 (0.45–0.90)	.013*
Bowel resection	0.78 (0.56–1.08)	0.145	0.36 (0.14–0.90)	0.024*	1.33 (0.96–1.85)	0.101	0.61 (0.43–0.87)	0.008*	0.54 (0.38–0.76)	.0004*
Smoker at diagnosis	0.88 (0.57–1.37)	0.578	0.60 (0.28–1.29)	0.192	0.96 (0.62–1.49)	0.911	0.75 (0.48–1.16)	0.219	0.98 (0.65–1.48)	1.00
Any EIMs	0.64 (0.41–1.00)	0.057	0.32 (0.08–1.32)	0.116	1.46 (0.93–2.30)	0.116	0.52 (0.31–0.88)	0.016*	0.65 (0.41–1.03)	.069

*remains significant after multiple testing correction applied using the FDR.