IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population

Table 4

Haplotype analysis of IL23R SNPs block 1.

(a)

Haplotype	rs11805303	rs7517847	Hap-score	Control Hap-frequencies	Case hap-frequencies	Pool hap-frequencies	𝑃
1	C	G	−3.48	0.450	0.358	0.409	.0005	global-stat = 15.6
2	C	T	1.17	0.245	0.275	0.258	.241	df = 3
3	T	T	2.24	0.305	0.359	0.329	.025	𝐏=.𝟎𝟎𝟏
4	T	G	NA	3.4𝐸−10	0.008	0.003	NA

(b)

Haplotype	rs10889677	rs11209026	rs1343151	Hap-score	Control hap-frequencies	Case hap-frequencies	Pool hap-frequencies	𝑃
1	C	G	A	−2.69	0.296	0.232	0.268	.007	global-stat = 13.4
2	C	A	A	−1.90	0.069	0.044	0.058	.058	df = 4
3	C	G	G	1.62	0.310	0.350	0.328	.105	𝐏=.𝟎𝟎𝟗
4	A	G	G	1.91	0.323	0.374	0.346	.056
5	A	G	A	NA	0.002	3.1𝐸−09	0.001	NA
6	C	A	G	NA	6.1𝐸−10	NA	5.3𝐸−10	NA