IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population

Table 5

The statistical interaction between IL23R SNPs and NOD2 genotype.

	NOD2
IL23R	d/d (𝑛 = 557)				d/D (𝑛 = 95)				D/D (𝑛 = 19)
	Control	Case	OR (95% CI)	𝑃	Control	Case	OR (95% CI)	𝑃	Control	Case
rs10889677
A/A	40	27	0.81 (0.46–1.40)		8	8	0.35 (0.11–1.15)	0.147	0	1
A/C	130	109	1.00	.103	12	34	1.00		2	8
C/C	156	88	0.67 (0.47–0.97)		14	19	0.48 (0.19–1.24)		0	8
rs11209026
A/A	6	0	—		0	0	—		0	0
A/G	33	22	0.95 (0.54–1.68)	.986	5	2	0.20 (0.04–1.08)	0.061	0	1
G/G	289	202	1.00		29	59	1.00		2	16
rs11805303
C/C	160	94	1.00		13	18	1.00	0.056	0	7
C/T	137	98	1.22 (0.85–1.75)	.140	12	37	2.23 (0.85–5.85)		2	9
T/T	28	29	1.76 (0.99–3.14)		8	6	0.54 (0.15–1.94)		0	1
rs1343151
A/A	54	10	0.23 (0.11–0.47)		2	4	0.94 (0.16–5.69)	0.615	0	0
A/G	140	105	0.93 (0.65–1.33)	.0003	16	22	0.65 (0.27–1.55)		0	9
G/G	134	108	1.00		16	34	1.00		2	8
rs7517847
G/G	64	24	0.45 (0.26–0.79)		4	3	0.60 (0.12–3.08)	0.156	0	0
G/T	172	121	0.84 (0.57–1.24)	.018	14	36	2.06 (0.84–5.07)		2	6
T/T	91	76	1.00		16	20	1.00		0	10