Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma

Figure 8

Effects of rosuvastatin on HUVEC functions. (a) Proliferation of HUVECs with or without rosuvastatin (0–100 μM). Results, expressed as number of HUVECs per well, are the mean ± SD of three experiments performed in quintuplicate. (b) Effect of rosuvastatin (25 μM) on the formation of capillary-like structures by HUVECs in Matrigel. (c) Quantifications of the number of sprouts/mm² results were the mean ± SD of three experiments done in duplicate. (d) Rho activation assays in HUVECs with (25 μM and 100 μM) and without rosuvastatin treatment. Results, expressed as absorbance, are the mean ± SD of three experiments performed in duplicate, ^∗∗𝑃<.01 and ^∗∗∗𝑃<.001.

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