Review Article
The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
Table 2
Importance of IL-12-IFN- axis for in vivo LPS sensitization by P. acnes treatment. Mice with various genotypes were sequentially administered with P. acnes and LPS. At day 7 after P. acnes priming, hepatic granuloma formation was determined by histological analyses.
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indicates that 20% and more area of the liver section is occupied by granulomas; − indicates no granulomas. indicates more than C reduction of rectal temperature after LPS challenge; − indicates less than C of it. indicates more than 10 g/mL of plasma TAT levels; − indicates normal range of them ( 50 ng/mL); indicates 50 ng/mL and 200 ng/mL. indicates more than 5 ng/mL; − indicates less than 0.1 ng/mL. were monitored for 48 h after LPS challenge. indicates more than 300 IU of serum ALT levels; − indicates normal range of them ( 50 IU). |