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Gastroenterology Research and Practice
Volume 2010, Article ID 758397, 7 pages
http://dx.doi.org/10.1155/2010/758397
Clinical Study

Troxipide in the Management of Gastritis: A Randomized Comparative Trial in General Practice

Medical Services Department, Zuventus Healthcare Ltd, 5119, ‘D’ Wing, Oberoi Garden Estates, Chandivali, Mumbai 400072, India

Received 2 August 2010; Revised 29 September 2010; Accepted 13 October 2010

Academic Editor: R. Fass

Copyright © 2010 Bhupesh Dewan and Aarthi Balasubramanian. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. H. Katelaris, G. H. K. Tippett, P. Norbu, D. G. Lowe, R. Brennan, and M. J. G. Farthing, “Dyspepsia, Helicobacter pylori, and peptic ulcer in a randomly selected population in India,” Gut, vol. 33, no. 11, pp. 1462–1466, 1992. View at Google Scholar · View at Scopus
  2. I. Wiklund, “Review of the quality of life and burden of illness in gastroesophageal reflux disease,” Digestive Diseases, vol. 22, no. 2, pp. 108–114, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. M. P. Sharma and V. Ahuja, “Current management of acid peptic disorders,” Journal, Indian Academy of Clinical Medicine, vol. 4, no. 3, pp. 228–233, 2003. View at Google Scholar
  4. S. Y. Seol, M. H. Kim, J. S. Ryu, M. G. Choi, D. W. Shin, and B. O. Ahn, “DA-9601 for erosive gastritis: results of a double-blind placebo-controlled phase III clinical trial,” World Journal of Gastroenterology, vol. 10, no. 16, pp. 2379–2382, 2004. View at Google Scholar · View at Scopus
  5. L. Laine, K. Takeuchi, and A. Tarnawski, “Gastric mucosal defense and cytoprotection: bench to bedside,” Gastroenterology, vol. 135, no. 1, pp. 41–60, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. J. L. Wallace and D. N. Granger, “The cellular and molecular basis of gastric mucosal defense,” FASEB Journal, vol. 10, no. 7, pp. 731–740, 1996. View at Google Scholar · View at Scopus
  7. S. K. Lam, “Why do ulcers heal with sucralfate?” Scandinavian Journal of Gastroenterology, Supplement, vol. 25, no. S173, pp. 6–16, 1990. View at Google Scholar · View at Scopus
  8. Y. Hyeoyun and Y. Huh, “Clinical trial of troxipide in peptic ulcer,” Modern Medicine, vol. 32, no. 3, pp. 125–131, 1989. View at Google Scholar
  9. Anon, “Aplace®,” Kyorin Pharmaceuticals, Tokyo, Japan, 2010, http://www.kyorin-pharm.co.jp/prodinfo/medicine/pdf/Aplace.pdf.
  10. T. Mine, A. Kataoka, and A. Kataoka, “Effects of cimetidine and troxipide on gastric mucosal prostaglandin synthesis in patients with chronic gastric ulcer,” Current Therapeutic Research, vol. 50, no. 6, pp. 878–887, 1991. View at Google Scholar · View at Scopus
  11. K. Kusugami, K. Ina, T. Hosokawa, F. Kobayashi, H. Kusajima, K. Momo, and Y. Nishio, “Troxipide, a novel antiulcer compound, has inhibitory effects on human neutrophil migration and activation induced by various stimulants,” Digestive and Liver Disease, vol. 32, no. 4, pp. 305–311, 2000. View at Google Scholar · View at Scopus
  12. M. Inoue, M. Takahashi, Y. Ishibashi, S. Sueyoshi, F. Kobayashi, and S. Matsuzawa, “Effects of troxipide on the prednisolone-induced aggravation of gastric mucosal lesions occurred by HC1 in rats,” Japanese Pharmacology and Therapeutics, vol. 33, no. 8, pp. 757–763, 2005. View at Google Scholar
  13. K. Momo, K. Hoshina, Y. Ishibashi, and T. Saito, “Preventive effects of troxipide on a newly developed model of acute gastric mucosal lesion (AGML) induced by ischemia/reperfusion plus ammonia in the rat,” Folia Pharmacologica Japonica, vol. 104, no. 4, pp. 313–323, 1994. View at Google Scholar
  14. H. Matsui, Y. Murata, and Y. Murata, “Diclofenac-induced gastric mucosal fluorescence in rats,” Digestive Diseases and Sciences, vol. 46, no. 2, pp. 338–344, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Wang, L. Zhang, Z. Fang, A. Fan, and Y. Wang, “The pharmacodynamics of troxipide on experimental gastric ulcers in rats,” Journal of West China University of Medical Sciences, vol. 24, no. 3, pp. 313–316, 1993. View at Google Scholar · View at Scopus
  16. Y. Abe, H. Sekiguchi, K. Tsuru, and T. Irikura, “Effects of 3,4,5-trimethoxy-N-(3-piperidyl) benzamide (KU-54) on the incorporation (excretion) 14C-glucosamine in the gastric mucosa and the liver of rats,” Folia Pharmacologica Japonica, vol. 84, no. 1, pp. 11–18, 1984. View at Google Scholar
  17. Y. Abe, H. Sekiguchi, K. Tsuru, and T. Irikura, “Effects of 3,4,5-trimethoxy-N-(3-piperidyl) benzamide (KU-54) on the respiration of the gastric mucosa and liver in rats,” Folia Pharmacologica Japonica, vol. 83, no. 4, pp. 317–324, 1984. View at Google Scholar
  18. Y. Abe, T. Irikura, K. Momo, and K. Tsuru, “Influence of 3-(3,4,5-trimethoxybenzamido) piperidine (KU-54) on gastric mucosal blood flow,” Folia Pharmacologica Japonica, vol. 76, no. 5, pp. 355–361, 1980. View at Google Scholar
  19. H. Sekiguchi, K. Hamada, Y. Okada, and F. Taga, “Effects of troxipide on acute gastric lesions in rats,” Folia Pharmacologica Japonica, vol. 89, no. 3, pp. 111–119, 1987. View at Google Scholar
  20. H. Sekiguchi, K. Hamada, F. Taga, and K. Nishino, “Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats,” Arzneimittel-Forschung, vol. 43, no. 2, pp. 134–138, 1993. View at Google Scholar · View at Scopus
  21. G. N. J. Tytgat, “The Sydney system: endoscopic division. Endoscopic appearances in gastritis/duodenitis,” Journal of Gastroenterology and Hepatology, vol. 6, no. 3, pp. 223–234, 1991. View at Google Scholar · View at Scopus
  22. M. F. Dixon, R. M. Genta, and R. M. Genta, “Classification and grading of Gastritis: the updated Sydney system,” American Journal of Surgical Pathology, vol. 20, no. 10, pp. 1161–1181, 1996. View at Publisher · View at Google Scholar
  23. S. L. Collins, R. A. Moore, and H. J. McQuay, “The visual analogue pain intensity scale: what is moderate pain in millimetres?” Pain, vol. 72, no. 1-2, pp. 95–97, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. M. P. Jensen, C. Chen, and A. M. Brugger, “Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain,” Journal of Pain, vol. 4, no. 7, pp. 407–414, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Ashby, “Treatment of gastroesophageal reflux disease in a managed care environment,” American Journal of Managed Care, vol. 6, no. 9, pp. S480–S483, 2000. View at Google Scholar · View at Scopus
  26. I. A. Eland, C. Huerta Alvarez, B. H. Ch Stricker, and L. A. García Rodrfguez, “The risk of acute pancreatitis associated with acid-suppressing drugs,” British Journal of Clinical Pharmacology, vol. 49, no. 5, pp. 473–478, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. E. J. Gallagher, P. E. Bijur, C. Latimer, and W. Silver, “Reliability and validity of a visual analog scale for acute abdominal pain in the ED,” American Journal of Emergency Medicine, vol. 20, no. 4, pp. 287–290, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. A.-M. Kelly, “Setting the benchmark for research in the management of acute pain in emergency departments,” Emergency Medicine, vol. 13, no. 1, pp. 57–60, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. B. A. Lord and B. Parsell, “Measurement of pain in the prehospital setting using a visual analogue scale,” Prehospital and Disaster Medicine, vol. 18, no. 4, pp. 353–358, 2003. View at Google Scholar · View at Scopus
  30. M. Ruth, I. Mansson, and N. Sandberg, “The prevalence of symptoms suggestive of esophageal disorders,” Scandinavian Journal of Gastroenterology, vol. 26, no. 1, pp. 73–81, 1991. View at Google Scholar · View at Scopus
  31. D. Armstrong, “Symptom assessment: methods and content,” Journal of Clinical Gastroenterology, vol. 41, no. 2, pp. S184–S192, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Prasad, M. Mathan, G. Chandy, D. P. Rajan, S. Venkateswaran, B. S. Ramakrishna, and V. I. Mathan, “Prevalence of Helicabacter pylori in southern Indian controls and patients with gastroduodenal disease,” Journal of Gastroenterology and Hepatology, vol. 9, no. 5, pp. 501–506, 1994. View at Google Scholar · View at Scopus
  33. V. Kate, N. Ananthakrishnan, S. Badrinath, S. K. Amarnath, M. Balamurugan, and C. Ratnakar, “Helicobacter pylori infection and erosive gastritis,” Journal of Association of Physicians of India, vol. 46, no. 5, pp. 436–437, 1998. View at Google Scholar · View at Scopus
  34. J. P. Seery, D. J. Henshaw, P. J. Sandhu, H. M. Mather, F. Ahmad, I. McNeil, and J. D. Arnold, “Helicobacter pylori infection and upper gastrointestinal pathology in a British immigrant Indian community,” European Journal of Gastroenterology and Hepatology, vol. 9, no. 2, pp. 191–194, 1997. View at Google Scholar · View at Scopus
  35. K. K. Prasad, B. R. Thapa, S. Lal, A. K. Sharma, C. K. Nain, and K. Singh, “Lymphocytic gastritis and celiac disease in Indian children: evidence of a positive relation,” Journal of Pediatric Gastroenterology and Nutrition, vol. 47, no. 5, pp. 568–572, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. V. Singh, B. Trikha, C. K. Nain, K. Singh, and K. Vaiphei, “Epidemiology of Helicobacter pylori and peptic ulcer in India,” Journal of Gastroenterology and Hepatology, vol. 17, no. 6, pp. 659–665, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. D. K. Bhasin, B. C. Sharma, S. K. Sinha, P. Ray, K. Vaiphei, and K. Singh, “Helicobacter pylori eradication: comparison of three treatment regimens in India,” Journal of Clinical Gastroenterology, vol. 28, no. 4, pp. 348–351, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. R. J. F. Laheij, H. Straatman, J. B. M. J. Jansen, and A. L. M. Verbeek, “Evaluation of commercially available Helicobacter pylori serology kits: a review,” Journal of Clinical Microbiology, vol. 36, no. 10, pp. 2803–2809, 1998. View at Google Scholar · View at Scopus
  39. NICE, “Dyspepsia: management of dyspepsia in adults in primary care,” Clinical Guideline no. 17, 2004, http://www.nice.org.uk/CG017NICEguideline.
  40. P. Malfertheiner, F. Megraud, and F. Megraud, “Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report,” Gut, vol. 56, no. 6, pp. 772–781, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. B. S. Ramakrishna, “Helicobacter pylori infection in India: the case against eradication,” Indian Journal of Gastroenterology, vol. 25, no. 1, pp. 25–28, 2006. View at Google Scholar · View at Scopus
  42. H. Gudjónsson, E. Oddsson, and E. Oddsson, “Efficacy of sucralfate in treatment of non-ulcer dyspepsia: a double-blind placebo-controlled study,” Scandinavian Journal of Gastroenterology, vol. 28, no. 11, pp. 969–972, 1993. View at Google Scholar · View at Scopus
  43. M. I. Kairaluoma, R. Hentilae, and R. Hentilae, “Sucralfate versus placebo in treatment of non-ulcer dyspepsia,” American Journal of Medicine, vol. 83, no. 3, supplement 2, pp. 51–55, 1987. View at Google Scholar · View at Scopus
  44. S. P. Misra, M. Dwivedi, V. Misra, and S. K. Agarwal, “Sucralfate versus ranitidine in non-ulcer dyspepsia: results of a prospective, randomized, open, controlled trial,” Indian Journal of Gastroenterology, vol. 11, no. 1, pp. 7–8, 1992. View at Google Scholar · View at Scopus
  45. M. Guslandi, “Comparison of sucralfate and ranitidine in the treatment of chronic nonerosive gastritis. A randomized, multicenter trial,” American Journal of Medicine, vol. 86, no. 6, supplement 1, pp. 45–48, 1989. View at Google Scholar · View at Scopus
  46. B. Dewan and N. Sahu, “Bioequivalence study of troxipide tablet formulations,” Journal of Bioequivalence & Bioavailability, vol. 2, pp. 50–54, 2010. View at Google Scholar