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Gastroenterology Research and Practice
Volume 2011, Article ID 123743, 4 pages
http://dx.doi.org/10.1155/2011/123743
Case Report

Two Patients with Extremely Elevated Tumor Markers: Where Is the Malignancy?

1Departments of Internal Medicine, Gastroenterology, and Hepatology, Medisch Centrum Haaglanden, P.O. Box 432, 2501 CK The Hague, The Netherlands
2Department of Gastroenterology and Hepatology, Isala Clinics, P.O. Box 10500, 8000 GM Zwolle, The Netherlands
3Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Received 3 March 2011; Accepted 26 April 2011

Academic Editor: Stuart Sherman

Copyright © 2011 Patrick P. J. van der Veek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Di Bisceglie, R. K. Sterling, R. T. Chung et al., “Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C trial,” Journal of Hepatology, vol. 43, no. 3, pp. 434–441, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Bruix, M. Sherman, J. M. Llovet et al., “Clinical management of hepatocellular carcinoma: conclusions of the Barcelona-2000 EASL conference: European Association for the Study of the Liver,” Journal of Hepatology, vol. 35, no. 3, pp. 421–430, 2001. View at Google Scholar
  3. D. S. Chen , J. L. Sung, J. C. Sheu et al., “Serum alpha-fetoprotein in the early stage of human hepatocellular carcinoma,” Gastroenterology, vol. 86, no. 6, pp. 1404–1409, 1984. View at Google Scholar
  4. K. Yamazaki, T. Kamiyama, S. Shiba et al., “An aged male patient with autoimmune hepatitis complicated by hepatocellular carcinoma,” Internal Medicine, vol. 38, no. 5, pp. 422–425, 1999. View at Google Scholar · View at Scopus
  5. Y. Motoo, T. Wakatsuki, N. Tanaka et al., “Resected case of hepatocellular carcinoma associated with lupoid hepatitis,” Journal of Gastroenterology and Hepatology, vol. 4, no. 3, pp. 295–298, 1989. View at Google Scholar · View at Scopus
  6. A. W. Jakobovits, P. R. Gibson, and F. J. Dudley, “Primary liver cell carcinoma complicating autoimmune chronic active hepatitis,” Digestive Diseases and Sciences, vol. 26, no. 8, pp. 694–699, 1981. View at Google Scholar · View at Scopus
  7. J. Meza-Junco, A. J. Montaño-Loza, B. Martínez-Benitez, and E. Kimura-Hayama, “Hepatocellular carcinoma in patients with autoimmune liver diseases: two case reports and literature review,” Annals of Hepatology, vol. 6, no. 2, pp. 122–126, 2007. View at Google Scholar · View at Scopus
  8. N. S. Goldstein, D. E. Blue, R Hankin et al., “Serum alpha-fetoprotein levels in patients with chronic hepatitis C: relationships with serum alanine aminotransferase values, histologic activity index, and hepatocyte MIB-1 scores,” American Journal of Clinical Pathology, vol. 111, no. 6, pp. 811–816, 1999. View at Google Scholar
  9. N. V. Engelhardt, V. N. Baranov, M. N. Lazareva, and A. I. Goussev, “Ultrastructural localisation of alpha-fetoprotin (AFP) in regenerating mouse liver poisoned with CCL4. 1: reexpression of AFP in differentiated hepatocytes,” Histochemistry, vol. 80, no. 4, pp. 401–407, 1984. View at Google Scholar · View at Scopus
  10. F. C. Liu, D. M. Chang, J. H. Lai et al., “Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report,” Rheumatology International, vol. 27, no. 5, pp. 489–491, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. S. Ito and F. Gejyo, “Elevation of serum CA19-9 levels in benign diseases,” Internal Medicine, vol. 38, no. 11, pp. 840–841, 1999. View at Google Scholar · View at Scopus
  12. D. V. Mann, R. Edwards, S. Ho, W. Y. Lau, and G. Glazer, “Elevated tumour marker CA19-9: clinical interpretation and influence of obstructive jaundice,” European Journal of Surgical Oncology, vol. 26, no. 5, pp. 474–479, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. H. J. Kim, M. H. Kim, S. J. Myung et al., “A new strategy for the application of CA19-9 in the differentiation of pancreaticobiliary cancer: analysis using a receiver operating characteristic curve,” American Journal of Gastroenterology, vol. 94, no. 7, pp. 1941–1946, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. Principe, M. Del Gaudio, G. L. Grazi, U. Paolucci, and A. Cavallari, “Mirizzi syndrome with cholecysto-choledocal fistula with a high CA19-9 level mimicking biliary malignancies: a case report,” Hepato-Gastroenterology, vol. 50, no. 53, pp. 1259–1262, 2003. View at Google Scholar · View at Scopus