Involvement of COX-2/PGE2 Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer
Figure 4
Downregulation of MMP-9 by COX-2 siRNA (a) Western blotting revealed expression of COX-2 was absent in BxPC-3 and Capan-1 after transfection with COX-2 siRNA plasmid. (b) After transfection with COX-2 siRNA plasmid, MMP-9 mRNA expression was downregulated significantly in BxPC-3 and Capan-1 cells, compared with cells with control siRNA (*, resp., versus control siRNA) or cells without siRNA (**, resp., versus no siRNA). Data are expressed as mean ± SD, .
