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Gastroenterology Research and Practice
Volume 2011, Article ID 235796, 6 pages
http://dx.doi.org/10.1155/2011/235796
Research Article

Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease

1Department of Medicine, Faculty of Medicine, University Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
2Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Community Health, Faculty of Medicine, University Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
4Sentosa Kajang Medical Centre, 43000 Kajang, Selangor, Malaysia

Received 15 February 2011; Revised 23 March 2011; Accepted 9 April 2011

Academic Editor: Edoardo G. Giannini

Copyright © 2011 Hamizah Razlan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. A. Bravo, S. G. Sheth, and S. Chopra, “Liver biopsy,” New England Journal of Medicine, vol. 344, no. 7, pp. 495–500, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Poniachik, D. E. Bernstein, K. R. Reddy et al., “The role of laparoscopy in the diagnosis of cirrhosis,” Gastrointestinal Endoscopy, vol. 43, no. 6, pp. 568–571, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Jalan and P. C. Hayes, “Review article: quantitative tests of liver function,” Alimentary Pharmacology and Therapeutics, vol. 9, no. 3, pp. 263–270, 1995. View at Google Scholar · View at Scopus
  4. C. G. Child and J. G. Turcotte, “Surgery and portal hypertension,” Major Problems in Clinical Surgery, vol. 1, pp. 1–85, 1964. View at Google Scholar · View at Scopus
  5. R. N. H. Pugh, I. M. Murray Lyon, and J. L. Dawson, “Transection of the oesophagus for bleeding oesophageal varices,” British Journal of Surgery, vol. 60, no. 8, pp. 646–649, 1973. View at Google Scholar
  6. S. Klatt, C. Taut, D. Mayer, G. Adler, and K. Beckh, “Evaluation of the C-methacetin breath test for quantitative liver function testingEvaluation des C-methacetin-atemtests als quantitativer leberfunktionstest,” Zeitschrift fur Gastroenterologie, vol. 35, no. 8, pp. 609–614, 1997. View at Google Scholar · View at Scopus
  7. P. Krumbiegel, K. Gunther, and H. Faust, “Nuclear medicine liver function tests for pregnant women and children—1. Breath tests with 14C-methacetin and 13C-methacetin,” European Journal of Nuclear Medicine, vol. 10, no. 3-4, pp. 129–133, 1985. View at Google Scholar
  8. S. Lara Baruque, M. Razquin, I. Jimenez, A. Vazquez, J. P. Gisbert, and J. M. Pajares, “13C-Phenylalanine and C-Methacetin breath test to evaluate functional capacity of hepatocyte in chronic liver disease,” Digestive and Liver Disease, vol. 32, no. 3, pp. 226–232, 2000. View at Google Scholar · View at Scopus
  9. A. Armuzzi, M. Candelli, M. A. Zocco et al., “Review article: breath testing for human liver function assessment,” Alimentary Pharmacology and Therapeutics, vol. 16, no. 12, pp. 1977–1996, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. R. J. Adamek, O. Goetze, C. Boedeker, B. Pfaffenbach, A. Luypaerts, and B. Geypens, “13C-methacetin breath test: isotope-selective nondispersive infrared spectrometry in comparison to isotope ratio mass spectrometry in volunteers and patients with liver cirrhosis,” Zeitschrift fur Gastroenterologie, vol. 37, no. 12, pp. 1139–1143, 1999. View at Google Scholar · View at Scopus
  11. K. Matsumoto, M. Suehiro, and M. Iio, “[13C]Methacetin breath test for evaluation of liver damage,” Digestive Diseases and Sciences, vol. 32, no. 4, pp. 344–348, 1987. View at Google Scholar
  12. J. Holtmeier, M. Leuschner, A. Schneider, U. Leuschner, W. F. Caspary, and B. Braden, “13C-methacetin and 13C-galactose breath tests can assess restricted liver function even in early stages of primary biliary cirrhosis,” Scandinavian Journal of Gastroenterology, vol. 41, no. 11, pp. 1336–1341, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. F. Liaw, N. Leung, J. H. Kao et al., “Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update,” Hepatology International, vol. 2, no. 3, pp. 263–283, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. G. W. McCaughan, M. Omata, D. Amarapurkar et al., “Asian pacific association for the study of the liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection,” Journal of Gastroenterology and Hepatology, vol. 22, no. 5, pp. 615–633, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. P. J. Scheuer, “Classification of chronic viral hepatitis: a need for reassessment,” Journal of Hepatology, vol. 13, no. 3, pp. 372–374, 1991. View at Google Scholar · View at Scopus
  16. M. Candelli, I. A. Cazzato, M. A. Zocco et al., “13C-Breath tests in the study of mitochondrial liver function,” European Review for Medical and Pharmacological Sciences, vol. 8, no. 1, pp. 23–31, 2004. View at Google Scholar · View at Scopus
  17. J. A. Hanley and B. J. McNeil, “The meaning and use of the area under a receiver operating characteristic (ROC) curve,” Radiology, vol. 143, no. 1, pp. 29–36, 1982. View at Google Scholar · View at Scopus
  18. M. C. Weinstein and H. V. Fineberg, Clinical Decision Analysis, W. B. Saaunders, Philadelphia, Pa, USA, 1980.
  19. B. Braden, D. Faust, U. Sarrazin et al., “13C-methacetin breath test as liver function test in patients with chronic hepatitis C virus infection,” Alimentary Pharmacology and Therapeutics, vol. 21, no. 2, pp. 179–185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Festi, S. Capodicasa, L. Sandri et al., “Measurement of hepatic functional mass by means of C-methacetin and C-phenylalanine breath tests in chronic liver disease: comparison with Child-Pugh score and serum bile acid levels,” World Journal of Gastroenterology, vol. 11, no. 1, pp. 142–148, 2005. View at Google Scholar · View at Scopus
  21. A. Schneider, W. F. Caspary, R. Saich et al., “13C-methacetin breath test shortened: 2-point-measurements after 15 minutes reliably indicate the presence of liver cirrhosis,” Journal of Clinical Gastroenterology, vol. 41, no. 1, pp. 33–37, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Dinesen, W. F. Caspary, R. W. Chapman, C. F. Dietrich, C. Sarrazin, and B. Braden, “13C-methacetin-breath test compared to also noninvasive biochemical blood tests in predicting hepatic fibrosis and cirrhosis in chronic hepatitis C,” Digestive and Liver Disease, vol. 40, no. 9, pp. 743–748, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Lalazar, O. Pappo, T. Hershcovici et al., “A continuous 13C methacetin breath test for noninvasive assessment of intrahepatic inflammation and fibrosis in patients with chronic HCV infection and normal ALT,” Journal of Viral Hepatitis, vol. 15, no. 10, pp. 716–728, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Petrolati, D. Festi, G. De Berardinis et al., “13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation,” Alimentary Pharmacology and Therapeutics, vol. 18, no. 8, pp. 785–790, 2003. View at Publisher · View at Google Scholar
  25. Y. X. Liu, L. Y. Huang, C. R. Wu, and J. Cui, “Measurement of liver function for patients with cirrhosis by 13C-methacetin breath test compared with Child-Pugh score and routine liver function tests,” Chinese Medical Journal, vol. 119, no. 18, pp. 1563–1566, 2006. View at Google Scholar · View at Scopus