Fecal Molecular Markers for Colorectal Cancer Screening

Table 1

Studies of KRAS genetic alterations in fecal samples.

Authors and reference	Technique	Specimen	Specimen 𝑛 =	Control 𝑛 =	Sensitivity	Specificity
Zhang et al. [39]	Chip-based temperature gradient capillary electrophoresis (TGCE)	CRC	30	15	57%	93%
Chien et al. [40]	RT-PCR + amplified restricted fragment length polymorphism analysis	CRC	29	20	41%	95%
Rengucci et al. [41]	Denaturing gradient gel electrophoresis	CRC	46	18	33%	100%
Notarnicola et al. [42]	PCR amplification and restriction enzyme analysis	CRC	26	None	26.9%	NA
Smith-Ravin et al. [43]	PCR amplification using allele-specific mismatch method	CRC	11	None	50%	NA