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Gastroenterology Research and Practice
Volume 2012, Article ID 290231, 7 pages
http://dx.doi.org/10.1155/2012/290231
Research Article

Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation?

1Department of Medicine, Innlandet Hospital Trust, 2819 Gjøvik, Norway
2Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
3Department of Research, Innlandet Hospital Trust, 2381 Brumunddal, Norway

Received 29 November 2011; Accepted 22 December 2011

Academic Editor: P. Enck

Copyright © 2012 Gunvor S. Fosnes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. A. O'Keefe, N. J. Talley, A. R. Zinsmeister, and S. J. Jacobsen, “Bowel disorders impair functional status and quality of life in the elderly: a population-based study,” Journals of Gerontology—Series A, vol. 50, no. 4, pp. M184–M189, 1995. View at Google Scholar · View at Scopus
  2. P. D. R. Higgins and J. F. Johanson, “Epidemiology of constipation in North America: a systematic review,” American Journal of Gastroenterology, vol. 99, no. 4, pp. 750–759, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Belsey, S. Greenfield, D. Candy, and M. Geraint, “Systematic review: impact of constipation on quality of life in adults and children,” Alimentary Pharmacology and Therapeutics, vol. 31, no. 9, pp. 938–949, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Gallagher and D. O'Mahony, “Constipation in old age,” Best Practice and Research, vol. 23, no. 6, pp. 875–887, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Hosia-Randell, M. Suominen, S. Muurinen, and K. H. Pitkälä, “Use of laxatives among older nursing home residents in Helsinki, Finland,” Drugs and Aging, vol. 24, no. 2, pp. 147–154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. K. N. van Dijk, C. S. ve Vries, P. B. van den Berg, A. M. Dijkema, J. R. B. J. Brouwers, and L. T. W. de Jong-van Den Berg, “Constipation as an adverse effect of drug use in nursing home patients: an overestimated risk,” British Journal of Clinical Pharmacology, vol. 46, no. 3, pp. 255–261, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. S. S. Rao and J. T. Go, “Update on the management of constipation in the elderly: new treatment options,” Clinical Interventions in Aging, vol. 5, pp. 163–171, 2010. View at Google Scholar
  8. J. H. Gurwitz, T. S. Field, J. Judge et al., “The incidence of adverse drug events in two large academic long-term care facilities,” American Journal of Medicine, vol. 118, no. 3, pp. 251–258, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. G. R. Locke, J. H. Pemberton, and S. F. Phillips, “Aga technical review on constipation,” Gastroenterology, vol. 119, no. 6, pp. 1766–1778, 2000. View at Google Scholar · View at Scopus
  10. J. C. Milton, I. Hill-Smith, and S. H. D. Jackson, “Prescribing for older people,” BMJ, vol. 336, no. 7644, pp. 606–609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Ruths, J. Straand, and H. A. Nygaard, “Multidisciplinary medication review in nursing home residents: what are the most significant drug-related problems? The Bergen District Nursing Home (BEDNURS) study,” Quality and Safety in Health Care, vol. 12, no. 3, pp. 176–180, 2003. View at Google Scholar · View at Scopus
  12. K. H. Halvorsen, S. Ruths, A. G. Granas, and K. K. Viktil, “Multidisciplinary intervention to identify and resolve drug-related problems in Norwegian nursing homes,” Scandinavian Journal of Primary Health Care, vol. 28, no. 2, pp. 82–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. A. Doshi, T. Shaffer, and B. A. Briesacher, “National estimates of medication use in nursing homes: findings from the 1997 medicare current beneficiary survey and the 1996 medical expenditure survey,” Journal of the American Geriatrics Society, vol. 53, no. 3, pp. 438–443, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. J. McLean and D. G. Le Couteur, “Aging biology and geriatric clinical pharmacology,” Pharmacological Reviews, vol. 56, no. 2, pp. 163–184, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. T. S. Field, J. H. Gurwitz, J. Avorn et al., “Risk factors for adverse drug events among nursing home residents,” Archives of Internal Medicine, vol. 161, no. 13, pp. 1629–1634, 2001. View at Google Scholar · View at Scopus
  16. E. R. Hajjar, J. T. Hanlon, M. B. Artz et al., “Adverse drug reaction risk factors in older outpatients,” American Journal Geriatric Pharmacotherapy, vol. 1, no. 2, pp. 82–89, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. MNA—Mini Nutritional Assessment, 2010, http://www.mna-elderly.com/mna_forms.html.
  18. G. F. Longstreth, W. G. Thompson, W. D. Chey, L. A. Houghton, F. Mearin, and R. C. Spiller, “Functional bowel disorders,” Gastroenterology, vol. 130, no. 5, pp. 1480–1491, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. WHO Collaborating Centre for Drug Statistics Methodology, 2010, http://www.whocc.no/.
  20. R. M. Carnahan, B. C. Lund, P. J. Perry, B. G. Pollock, and K. R. Gulp, “The anticholinergic drug scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity,” Journal of Clinical Pharmacology, vol. 46, no. 12, pp. 1481–1486, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. S. van Buuren, H. C. Boshuizen, and D. L. Knook, “Multiple imputation of missing blood pressure covariates in survival analysis,” Statistics in Medicine, vol. 18, no. 6, pp. 681–694, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. R. K. Wong, O. S. Palsson, M. J. Turner et al., “Inability of the Rome III criteria to distinguish functional constipation from constipation-subtype irritable bowel syndrome,” American Journal of Gastroenterology, vol. 105, no. 10, pp. 2228–2234, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. G. A. Digesu, D. Panayi, N. Kundi, P. Tekkis, R. Fernando, and V. Khullar, “Validity of the Rome III Criteria in assessing constipation in women,” International Urogynecology Journal and Pelvic Floor Dysfunction, vol. 21, no. 10, pp. 1185–1193, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Gage, C. Goodman, S. L. Davies et al., “Laxative use in care homes,” Journal of Advanced Nursing, vol. 66, no. 6, pp. 1266–1272, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. L. E. Tune, “Anticholinergic effects of medication in elderly patients,” Journal of Clinical Psychiatry, vol. 62, no. 22, pp. 11–14, 2001. View at Google Scholar · View at Scopus
  26. N. J. Talley, M. Jones, G. Nuyts, and D. Dubois, “Risk factors for chronic constipation based on a general practice sample,” American Journal of Gastroenterology, vol. 98, no. 5, pp. 1107–1111, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Pilotto, M. Franceschi, D. Vitale et al., “The prevalence of diarrhea and its association with drug use in elderly outpatients: a multicenter study,” American Journal of Gastroenterology, vol. 103, no. 11, pp. 2816–2823, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Harari, J. H. Gurwitz, J. Avorn, I. Choodnovskiy, and K. L. Minaker, “Correlates of regular laxative use by frail elderly persons,” American Journal of Medicine, vol. 99, no. 5, pp. 513–518, 1995. View at Publisher · View at Google Scholar · View at Scopus